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197. Chang YT, Kowalczyk M, Fogerson PM, Lee YJ, Haque M, Adams EL, Wang DC, DeNardo LA, Tessier-Lavigne M, Huguenard JR, Luo L, Huang WH (2022) blank Proc Natl Acad Sci U S A. 119:e2210122119.  

196. Revah O, Gore F, Kelley KW, Andersen J, Sakai N, Chen X, Li MY, Birey F, Yang X, Saw NL, Baker SW, Amin ND, Kulkarni S, Mudipalli R, Cui B, Nishino S, Grant GA, Knowles JK, Shamloo M, Huguenard JR, Deisseroth K, Pasca SP (2022) Maturation and circuit integration of transplanted human cortical organoids. Nature. 610:319-326. PMC9556304 

195. Knowles JK, Xu H, Soane C, Batra A, Saucedo T, Frost E, Tam LT, Fraga D, Ni L, Villar K, Talmi S, Huguenard JR, Monje M (2022) Maladaptive myelination promotes generalized epilepsy progression. Nat Neurosci. 25:596-606. PMC9076538 

194. Elleman AV, Devienne G, Makinson CD, Haynes AL, Huguenard JR, Du Bois J (2022) Author Correction: Precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin. Nat Commun. 13:2277.  

193. Elleman AV, Devienne G, Makinson CD, Haynes AL, Huguenard JR, Du Bois J (2021) Precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin. Nat Commun. 12:4171.  F1000 

192. Pan Y, Hysinger JD, Barron T, Schindler NF, Cobb O, Guo X, Yalçın B, Anastasaki C, Mulinyawe SB, Ponnuswami A, Scheaffer S, Ma Y, Chang KC, Xia X, Toonen JA, Lennon JJ, Gibson EM, Huguenard JR, Liau LM, Goldberg JL, Monje M, Gutmann DH (2021) NF1 mutation drives neuronal activity-dependent initiation of optic glioma. Nature. 594:277-282.  

191. Gordon A, Yoon SJ, Tran SS, Makinson CD, Park JY, Andersen J, Valencia AM, Horvath S, Xiao X, Huguenard JR, PaÈ™ca SP, Geschwind DH (2021) Long-term maturation of human cortical organoids matches key early postnatal transitions. Nat Neurosci. 24:331-342. PMC8109149 F1000 

190. Huguenard JR (2020) Perspective: Is Cortical Hyperexcitability the Only Path to Generalized Absence Epilepsy? Epilepsy Curr. 20:59S-61S. PMC7726732 

189. Koster AK, Reese AL, Kuryshev Y, Wen X, McKiernan KA, Gray EE, Wu C, Huguenard JR, Maduke M, Du Bois J (2020) Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel. Proc Natl Acad Sci U S A. 117:32711-32721. PMC7768775 

188. Khan TA, Revah O, Gordon A, Yoon SJ, Krawisz AK, Goold C, Sun Y, Kim CH, Tian Y, Li MY, Schaepe JM, Ikeda K, Amin ND, Sakai N, Yazawa M, Kushan L, Nishino S, Porteus MH, Rapoport JL, Bernstein JA, O’Hara R, Bearden CE, Hallmayer JF, Huguenard JR, Geschwin (2020) Neuronal defects in a human cellular model of 22q11.2 deletion syndrome. Nat Med. 26:1888-1898.  F1000 

187. Lu AC, Lee CK, Kleiman-Weiner M, Truong B, Wang M, Huguenard JR, Beenhakker MP (2020) Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic oscillations. Elife. 9:e59548. PMC7529462 

186. Huguenard J (2019) Current Controversy: Spikes, Bursts, and Synchrony in Generalized Absence Epilepsy: Unresolved Questions Regarding Thalamocortical Synchrony in Absence Epilepsy. Epilepsy Curr. 19:105-111. PMC6610415 

185. Marton RM, Miura Y, Sloan SA, Li Q, Revah O, Levy RJ, Huguenard JR, PaÈ™ca SP (2019) Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures. Nat Neurosci. 22:484-491. PMC6788758  ESI Highly Cited 

184. Yoon SJ, Elahi LS, PaÈ™ca AM, Marton RM, Gordon A, Revah O, Miura Y, Walczak EM, Holdgate GM, Fan HC, Huguenard JR, Geschwind DH, PaÈ™ca SP (2019) Reliability of human cortical organoid generation. Nat Methods. 16:75-78. PMC6677388  ESI Highly Cited 

183. Ha HTT, Leal-Ortiz S, Lalwani K, Kiyonaka S, Hamachi I, Mysore SP, Montgomery JM, Garner CC, Huguenard JR, Kim SA (2018) Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons. Front Mol Neurosci. 11:405. PMC6256285 

182. Ren J, Friedmann D, Xiong J, Liu CD, Ferguson BR, Weerakkody T, DeLoach KE, Ran C, Pun A, Sun Y, Weissbourd B, Neve RL, Huguenard J, Horowitz MA, Luo L (2018) Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems. Cell. 175:1–16. PMC6173627 F1000 

181. Sorokin JM, Paz JT, Huguenard JR (2017) Absence seizure susceptibility correlates with pre-ictal β oscillations. J Physiol Paris. DOI:10.1016/j.jphysparis.2017.05.004. PMC5607110 

180. Birey F, Andersen J, Makinson CD, Islam S, Wei W, Huber N, Fan HC, Metzler KRC, Panagiotakos G, Thom N, O’Rourke NA, Steinmetz LM, Bernstein JA, Hallmayer J, Huguenard JR, Pasca SP (2017) Assembly of functionally integrated human forebrain spheroids Nature. doi:10.1038/nature22047. PMC5805137 F1000  ESI Highly Cited  ESI Hot Paper 

179. Yackle K, Schwarz LA, Kam K, Sorokin JM, Huguenard JR, Feldman JL, Luo L, Krasnow MA (2017) Breathing control center neurons that promote arousal in mice. Science. 355:1411-1415. PMC5505554  F1000 

178. Makinson CD, Tanaka BS, Sorokin JM, Wong JC, Christian CA, Goldin AL, Escayg A, Huguenard JR (2017) Regulation of Thalamic and Cortical Network Synchrony by Scn8a. Neuron. 93:1165-1179. PMC5393918 F1000  SI

177. Sorokin JM, Davidson TJ, Frechette E, Abramian AM, Deisseroth K, Huguenard JR, Paz JT (2017) Bidirectional Control of Generalized Epilepsy Networks via Rapid Real-Time Switching of Firing Mode. Neuron. 93:194-210. PMC5268077  ESI Highly Cited 

176. Fogerson PM, Huguenard JR (2016) Tapping the Brakes: Cellular and Synaptic Mechanisms that Regulate Thalamic Oscillations. Neuron. 92:687-704. PMC5131525 

175. Fogerson PM, Huguenard JR (2016) Catching a wave. Elife. 5:pii: e21236. PMC5059133 

174. Brill J, Mattis J, Deisseroth K, Huguenard JR (2016) LSPS/Optogenetics to Improve Synaptic Connectivity Mapping: Unmasking the Role of Basket Cell-Mediated Feedforward Inhibition. eNeuro. 3:pii: ENEURO.0142-15.2016. PMC4976301 

173. Deleuze C, Huguenard JR (2016) Two classes of excitatory synaptic responses in rat thalamic reticular neurons. J Neurophysiol. 116:995-1011. PMC5009213 

172. Ha H, Huguenard J (2016) Criminal Minds: Cav3.2 Channels Are the Culprits, but NMDAR Are the Co-Conspirators. Epilepsy Curr. 16:36-8. PMC4749115 

171. Hiu T, Farzampour Z, Paz JT, Wang EH, Badgely C, Olson A, Micheva KD, Wang G, Lemmens R, Tran KV, Nishiyama Y, Liang X, Hamilton SA, O’Rourke N, Smith SJ, Huguenard JR, Bliss TM, Steinberg GK (2016) Enhanced phasic GABA inhibition during the repair phase of stroke: a novel therapeutic target. Brain. 139:468-80. PMC4805083 

170. Pangratz-Fuehrer S, Sieghart W, Rudolph U, Parada I, Huguenard JR (2016) Early Postnatal Switch in GABAAR α Subunits in the Reticular Thalamic Nucleus. J Neurophysiol. 115:1183-1195. PMC4808120 

169. Adamantidis A, Arber S, Bains JS, Bamberg E, Bonci A, Buzsáki G, Cardin JA, Costa RM, Dan Y, Goda Y, Graybiel AM, Häusser M, Hegemann P, Huguenard JR, Insel TR, Janak PH, Johnston D, Josselyn SA, Koch C, Kreitzer AC, Lüscher C, Malenka RC, Miesenböck (2015) Optogenetics: 10 years after ChR2 in neurons-views from the community. Nat Neurosci. 18:1202-1212. PMC4489980 

168. PaÅŸca AM, Sloan SA, Clarke LE, Tian Y, Makinson CD, Huber N, Kim CH, Park JY, O’Rourke NA, Nguyen KD, Smith SJ, Huguenard JR, Geschwind DH, Barres BA, PaÅŸca SP (2015) Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture. Nat Methods. 12:671-8. PMC4489980 F1000  ESI Highly Cited  ESI Hot Paper 

167. Weissberg I, Wood L, Kamintsky L, Vazquez O, Milikovsky DZ, Alexander A, Oppenheim H, Ardizzone C, Becker A, Frigerio F, Vezzani A, Buckwalter MS, Huguenard J, Friedman A, Kaufer D (2015) Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood-brain barrier dysfunction. Neurobiol Dis. 78:115-125. PMC4426044 

166. Ma Y, Juntti SA, Hu CK, Huguenard JR, Fernald RD (2015) Electrical synapses connect a network of gonadotropin releasing hormone neurons in a cichlid fish. Proc Natl Acad Sci U S A. 112:3805-10. PMC4378424 F1000 

165. Paz JT, Huguenard JR (2015) Microcircuits and their interactions in epilepsy: is the focus out of focus? Nat Neurosci. 18:351-359. PMC4561622  ESI Highly Cited 

164. Paz JT, Huguenard JR (2015) Optogenetics and epilepsy: past, present and future. Epilepsy Curr. 15:34-8. PMC4320957 

163. Farzampour Z, Huguenard J (2015) Seizing upon Mechanisms for Impaired Consciousness. Neuron. 85:453-5. PMC4554486 

162. Farzampour Z, Reimer RJ, Huguenard J (2015) Endozepines. Adv Pharmacol. 72:147-64. PMC4550098 

161. Bryant AS, Goddard CA, Huguenard JR, Knudsen EI (2015) Cholinergic control of gamma power in the midbrain spatial attention network. J Neurosci. 35:761-75. PMC4293421 

160. Makinson CD, Huguenard JR (2015) Attentional flexibility in the thalamus: now we’re getting SOMwhere. Nat Neurosci. 18:2-4. PMC4556356 

159. Leone DP, Heavner WE, Ferenczi EA, Dobreva G, Huguenard JR, Grosschedl R, McConnell SK (2015) Satb2 Regulates the Differentiation of Both Callosal and Subcerebral Projection Neurons in the Developing Cerebral Cortex. Cereb Cortex. 25:3406-19. PMC4585495 

158. Mattis J, Brill J, Evans S, Lerner TN, Davidson TJ, Hyun M, Ramakrishnan C, Deisseroth K, Huguenard JR (2014) Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection. J Neurosci. 34:11769-80. PMC4145178 

157. Goddard CA, Huguenard J, Knudsen E (2014) Parallel midbrain microcircuits perform independent temporal transformations. J Neurosci. 34:8130-8. PMC4051971 

156. Tani H, Dulla CG, Farzampour Z, Taylor-Weiner A, Huguenard JR, Reimer RJ (2014) A local glutamate-glutamine cycle sustains synaptic excitatory transmitter release. Neuron. 81:888-900. PMC4001919 F1000 

155. Goddard CA, Mysore SP, Bryant AS, Huguenard JR, Knudsen EI (2014) Spatially Reciprocal Inhibition of Inhibition within a Stimulus Selection Network in the Avian Midbrain. PLoS One. 9:e85865. PMC3897538 

154. Kyuyoung CL, Huguenard JR (2014) Modulation of short-term plasticity in the corticothalamic circuit by group III metabotropic glutamate receptors. J Neurosci. 34:675-87. PMC3870944 

153. Christian CA, Huguenard JR (2013) Astrocytes potentiate GABAergic transmission in the thalamic reticular nucleus via endozepine signaling. Proc Natl Acad Sci U S A. 110:20278-83. PMC3864346 

152. Christian CA, Huguenard JR (2013) Sniffer Patch Laser Uncaging REsponse (SPLURgE): an assay of regional differences in allosteric receptor modulation and neurotransmitter clearance. J Neurophysiol. 110:1722-31. PMC4042414 

151. Christian CA, Herbert AG, Holt RL, Peng K, Sherwood KD, Pangratz-Fuehrer S, Rudolph U, Huguenard JR (2013) Endogenous Positive Allosteric Modulation of GABAA Receptors by Diazepam binding inhibitor. Neuron. 78:1063-74. PMC3987987 F1000 

150. Dewolfe JL, Malow B, Huguenard J, Stickgold R, Bourgeois B, Holmes GL (2013) Sleep and epilepsy: a summary of the 2011 merritt-putnam symposium. Epilepsy Curr. 13:42-9. PMC3577087 

149. Ma Y, Huguenard JR (2013) Reemerging role of cable properties in action potential initiation. Proc Natl Acad Sci U S A. 110:3715-6. PMC3593907 

148. Paz JT, Davidson TJ, Frechette ES, Delord B, Parada I, Peng K, Deisseroth K, Huguenard JR (2013) Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury. Nat Neurosci. 16:64-70. PMC3700812 F1000  ESI Highly Cited 

147. Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, Gross RA, Gubitz AK, Hesterlee SE, Howells DW, Huguenard J, Kelner K, Koro (2012) A call for transparent reporting to optimize the predictive value of preclinical research. Nature. 490:187-91. PMC3511845  ESI Highly Cited 

146. Dulla CG, Tani H, Brill J, Reimer RJ, Huguenard JR (2012) Glutamate biosensor imaging reveals dysregulation of glutamatergic pathways in a model of developmental cortical malformation. Neurobiol Dis. 49C:232-246. PMC3574209 

145. Carter ME, Brill J, Bonnavion P, Huguenard JR, Huerta R, de Lecea L (2012) Mechanism for Hypocretin-mediated sleep-to-wake transitions. Proc Natl Acad Sci U S A. 109:E2635-44. PMC3465396 

144. Lacey CJ, Bryant A, Brill J, Huguenard JR (2012) Enhanced NMDA receptor-dependent thalamic excitation and network oscillations in stargazer mice. J Neurosci. 32:11067-81. PMC3430525 

143. Paz JT, Huguenard JR (2012) R U OK? The Novel Therapeutic Potential of R Channels in Epilepsy. Epilepsy Curr. 12:75-6. PMC3316366 

142. Goddard CA, Sridharan D, Huguenard JR, Knudsen EI (2012) Gamma oscillations are generated locally in an attention-related midbrain network. Neuron. 73:567-80. PMC3291715 

141. Zhang W, Huguenard JR, Buckmaster PS (2012) Increased excitatory synaptic input to granule cells from hilar and CA3 regions in a rat model of temporal lobe epilepsy. J Neurosci. 32:1183-96. PMC3778651 

140. Paz JT, Bryant AS, Peng K, Fenno L, Yizhar O, Frankel WN, Deisseroth K, Huguenard JR (2011) A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy. Nat Neurosci. 14:1167-73. PMC3308017  SI

139. Yizhar O, Fenno LE, Prigge M, Schneider F, Davidson TJ, O’Shea DJ, Sohal VS, Goshen I, Finkelstein J, Paz JT, Stehfest K, Fudim R, Ramakrishnan C, Huguenard JR, Hegemann P, Deisseroth K (2011) Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature. 477:171-8. PMC4155501 F1000  ESI Highly Cited  SI

138. Mao R, Schummers J, Knoblich U, Lacey CJ, Van Wart A, Cobos I, Kim C, Huguenard JR, Rubenstein JL, Sur M (2011) Influence of a Subtype of Inhibitory Interneuron on Stimulus-Specific Responses in Visual Cortex. Cereb Cortex. 22:493-508. PMC3278313 

137. Lee CK, Huguenard JR (2011) Martinotti cells: community organizers. Neuron. 69:1042-5. PMC3068616 

136. Beenhakker MP, Huguenard JR (2010) Astrocytes as gatekeepers of GABAB receptor function. J Neurosci. 30:15262-76. PMC3056552 

135. Manseau F, Marinelli S, Méndez P, Schwaller B, Prince DA, Huguenard JR, Bacci A (2010) Desynchronization of neocortical networks by asynchronous release of GABA at autaptic and synaptic contacts from fast-spiking interneurons. PLoS Biol. 8:. PMC2946936 

134. Jin X, Huguenard JR, Prince DA (2011) Reorganization of inhibitory synaptic circuits in rodent chronically injured epileptogenic neocortex. Cereb Cortex. 21:1094-104. PMC3077430 

133. Anderson TR, Huguenard JR, Prince DA (2010) Differential effects of Na+-K+ ATPase blockade on cortical layer V neurons. J Physiol. 588:4401-14. PMC3008847 

132. Paz JT, Christian CA, Parada I, Prince DA, Huguenard JR (2010) Focal cortical infarcts alter intrinsic excitability and synaptic excitation in the reticular thalamic nucleus. J Neurosci. 30:5465-79. PMC2861582 

131. Brill J, Huguenard JR (2010) Enhanced infragranular and supragranular synaptic input onto layer 5 pyramidal neurons in a rat model of cortical dysplasia. Cereb Cortex. 20:2926-38. PMC3003588 

130. Tani H, Dulla CG, Huguenard JR, Reimer RJ (2010) Glutamine is required for persistent epileptiform activity in the disinhibited neocortical brain slice. J Neurosci. 30:1288-300. PMC2821093 

129. Mignot E, Huguenard JR (2009) Resting our cortices by going DOWN to sleep. Neuron. 63:719-21.  

128. Bryant AS, Li B, Beenhakker MP, Huguenard JR (2009) Maintenance of thalamic epileptiform activity depends on the astrocytic glutamate-glutamine cycle. J Neurophysiol. 102:2880-8. PMC2777838 

127. Dulla CG, Huguenard JR (2009) Who let the spikes out? Nat Neurosci. 12:959-60. PMC2907263 

126. Beenhakker MP, Huguenard JR (2009) Neurons that fire together also conspire together: is normal sleep circuitry hijacked to generate epilepsy? Neuron. 62:612-32. PMC2748990 

125. Brill J, Huguenard JR (2009) Robust short-latency perisomatic inhibition onto neocortical pyramidal cells detected by laser-scanning photostimulation. J Neurosci. 29:7413-23. PMC2797487 F1000 

124. Kleiman-Weiner M, Beenhakker MP, Segal WA, Huguenard JR (2009) Synergistic roles of GABAA receptors and SK channels in regulating thalamocortical oscillations. J Neurophysiol. 102:203-13. PMC2712277 

123. Schofield CM, Kleiman-Weiner M, Rudolph U, Huguenard JR (2009) A gain in GABAA receptor synaptic strength in thalamus reduces oscillatory activity and absence seizures. Proc Natl Acad Sci U S A. 106:7630-5. PMC2678654 

122. Brill J, Huguenard JR (2008) Sequential changes in AMPA receptor targeting in the developing neocortical excitatory circuit. J Neurosci. 28:13918-28. PMC2706010 

121. Marinelli S, Pacioni S, Bisogno T, Di Marzo V, Prince DA, Huguenard JR, Bacci A (2008) The endocannabinoid 2-arachidonoylglycerol is responsible for the slow self-inhibition in neocortical interneurons. J Neurosci. 28:13532-41. PMC2615383 

120. Winsky-Sommerer R, Knapman A, Fedele DE, Schofield CM, Vyazovskiy VV, Rudolph U, Huguenard JR, Fritschy JM, Tobler I (2008) Normal sleep homeostasis and lack of epilepsy phenotype in GABA A receptor alpha3 subunit-knockout mice. Neuroscience. 154:595-605. PMC2587445 

119. Beyer B, Deleuze C, Letts VA, Mahaffey CL, Boumil RM, Lew TA, Huguenard JR, Frankel WN (2008) Absence seizures in C3H/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4. Hum Mol Genet. 17:1738-49. PMC2405903 

118. Yue BW, Huguenard JR (2001) The role of H-current in regulating strength and frequency of thalamic network oscillations. Thalamus Relat Syst. 1:95-103. PMC2222919 

117. Sun QQ, Huguenard JR, Prince DA (2005) Reorganization of barrel circuits leads to thalamically-evoked cortical epileptiform activity. Thalamus Relat Syst. 3:261-273. PMC2184932 

116. Dulla C, Tani H, Okumoto S, Frommer WB, Reimer RJ, Huguenard JR (2008) Imaging of glutamate in brain slices using FRET sensors. J Neurosci Methods. 168:306-19. PMC2267481 

115. Goddard CA, Knudsen EI, Huguenard JR (2007) Intrinsic excitability of cholinergic neurons in the rat parabigeminal nucleus. J Neurophysiol. 98:3486-93.  

114. Schofield CM, Huguenard JR (2007) GABA affinity shapes IPSCs in thalamic nuclei. J Neurosci. 27:7954-62.  

113. Huguenard JR, McCormick DA (2007) Thalamic synchrony and dynamic regulation of global forebrain oscillations. Trends Neurosci. 30:350-6.  

112. Shin J, Shen F, Huguenard J (2007) PKC and polyamine modulation of GluR2-deficient AMPA receptors in immature neocortical pyramidal neurons of the rat. J Physiol. 581:679-91. PMC2075192 

111. Kumar SS, Jin X, Buckmaster PS, Huguenard JR (2007) Recurrent circuits in layer II of medial entorhinal cortex in a model of temporal lobe epilepsy. J Neurosci. 27:1239-46.  

110. Staley KJ, Huguenard JR (2006) A thalamic sleep tonic. Epilepsy Curr. 6:164-6. PMC1783475 

109. Pangratz-Fuehrer S, Rudolph U, Huguenard JR (2007) Giant spontaneous depolarizing potentials in the developing thalamic reticular nucleus. J Neurophysiol. 97:2364-72.  

108. Li H, Huguenard JR, Fisher RS (2007) Gender and age differences in expression of GABAA receptor subunits in rat somatosensory thalamus and cortex in an absence epilepsy model. Neurobiol Dis. 25:623-30. PMC2708099 

107. Brill J, Kwakye G, Huguenard JR (2007) NPY signaling through Y1 receptors modulates thalamic oscillations. Peptides. 28:250-6. PMC1945169 

106. Tani H, Bandrowski AE, Parada I, Wynn M, Huguenard JR, Prince DA, Reimer RJ (2007) Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsy. Neurobiol Dis. 25:230-8. PMC1952182 

105. Deleuze C, Huguenard JR (2006) Distinct electrical and chemical connectivity maps in the thalamic reticular nucleus: potential roles in synchronization and sensation. J Neurosci. 26:8633-45.  F1000  SI

104. Brill J, Lee M, Zhao S, Fernald RD, Huguenard JR (2006) Chronic valproic acid treatment triggers increased neuropeptide y expression and signaling in rat nucleus reticularis thalami. J Neurosci. 26:6813-22.  

103. Halabisky B, Shen F, Huguenard JR, Prince DA (2006) Electrophysiological classification of somatostatin-positive interneurons in mouse sensorimotor cortex. J Neurophysiol. 96:834-45.  

102. Li H, Kraus A, Wu J, Huguenard JR, Fisher RS (2006) Selective changes in thalamic and cortical GABAA receptor subunits in a model of acquired absence epilepsy in the rat. Neuropharmacology. 51:121-8.  

101. Jin X, Prince DA, Huguenard JR (2006) Enhanced excitatory synaptic connectivity in layer v pyramidal neurons of chronically injured epileptogenic neocortex in rats. J Neurosci. 26:4891-900.  

100. Sohal VS, Pangratz-Fuehrer S, Rudolph U, Huguenard JR (2006) Intrinsic and synaptic dynamics interact to generate emergent patterns of rhythmic bursting in thalamocortical neurons. J Neurosci. 26:4247-55.  

99. Huntsman MM, Huguenard JR (2006) Fast IPSCs in rat thalamic reticular nucleus require the GABAA receptor beta1 subunit. J Physiol. 572:459-75. PMC1779681 

98. Sun QQ, Huguenard JR, Prince DA (2006) Barrel cortex microcircuits: thalamocortical feedforward inhibition in spiny stellate cells is mediated by a small number of fast-spiking interneurons. J Neurosci. 26:1219-30.  

97. Bacci A, Huguenard JR (2006) Enhancement of spike-timing precision by autaptic transmission in neocortical inhibitory interneurons. Neuron. 49:119-30.  F1000 

96. Sohal VS, Huguenard JR (2005) Inhibitory coupling specifically generates emergent gamma oscillations in diverse cell types. Proc Natl Acad Sci U S A. 102:18638-43. PMC1317969 

95. Bacci A, Huguenard JR, Prince DA (2005) Modulation of neocortical interneurons: extrinsic influences and exercises in self-control. Trends Neurosci. 28:602-10.  

94. Jin X, Huguenard JR, Prince DA (2005) Impaired Cl- extrusion in layer V pyramidal neurons of chronically injured epileptogenic neocortex. J Neurophysiol. 93:2117-26.  

93. Shin J, Shen F, Huguenard JR (2005) Polyamines modulate AMPA receptor-dependent synaptic responses in immature layer v pyramidal neurons. J Neurophysiol. 93:2634-43.  

92. Bacci A, Huguenard JR, Prince DA (2004) Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids. Nature. 431:312-6.  F1000 

91. Huguenard JR (2004) T-Channel Defects in Patients with Childhood Absence Epilepsy. Epilepsy Curr. 4:7-8. PMC324574 

90. Kumar SS, Huguenard JR (2003) Pathway-specific differences in subunit composition of synaptic NMDA receptors on pyramidal neurons in neocortex. J Neurosci. 23:10074-83.  F1000 

89. Huguenard J (2003) Neurotransmitter Supply and Demand in Epilepsy. Epilepsy Curr. 3:61-63. PMC321172 

88. Bacci A, Rudolph U, Huguenard JR, Prince DA (2003) Major differences in inhibitory synaptic transmission onto two neocortical interneuron subclasses. J Neurosci. 23:9664-74.  

87. Sun QQ, Baraban SC, Prince DA, Huguenard JR (2003) Target-specific neuropeptide Y-ergic synaptic inhibition and its network consequences within the mammalian thalamus. J Neurosci. 23:9639-49.  

86. Sohal VS, Huguenard JR (2003) Inhibitory interconnections control burst pattern and emergent network synchrony in reticular thalamus. J Neurosci. 23:8978-88.  

85. Sohal VS, Keist R, Rudolph U, Huguenard JR (2003) Dynamic GABA(A) receptor subtype-specific modulation of the synchrony and duration of thalamic oscillations. J Neurosci. 23:3649-57.  

84. Sun QQ, Prince DA, Huguenard JR (2003) Vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide activate hyperpolarization-activated cationic current and depolarize thalamocortical neurons in vitro. J Neurosci. 23:2751-8.  

83. Bandrowski AE, Huguenard JR, Prince DA (2003) Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex. J Neurophysiol. 89:1308-16. PMC3005275 

82. Bacci A, Huguenard JR, Prince DA (2003) Functional autaptic neurotransmission in fast-spiking interneurons: a novel form of feedback inhibition in the neocortex. J Neurosci. 23:859-66.  F1000 

81. Porcello DM, Smith SD, Huguenard JR (2003) Actions of U-92032, a T-type Ca2+ channel antagonist, support a functional linkage between I(T) and slow intrathalamic rhythms. J Neurophysiol. 89:177-85.  

80. Porcello DM, Huntsman MM, Mihalek RM, Homanics GE, Huguenard JR (2003) Intact synaptic GABAergic inhibition and altered neurosteroid modulation of thalamic relay neurons in mice lacking delta subunit. J Neurophysiol. 89:1378-86.  

79. Sohal VS, Huguenard JR (2002) Reciprocal inhibition controls the oscillatory state in thalamic networks Neurocomputing. 44-46:653-659.  

78. Bacci A, Huguenard JR, Prince DA (2002) Differential modulation of synaptic transmission by neuropeptide Y in rat neocortical neurons. Proc Natl Acad Sci U S A. 99:17125-30. PMC139280 

77. Sun QQ, Huguenard JR, Prince DA (2002) Somatostatin inhibits thalamic network oscillations in vitro: actions on the GABAergic neurons of the reticular nucleus. J Neurosci. 22:5374-86.  

76. Huguenard JR (2002) Block of T -Type Ca(2+) Channels Is an Important Action of Succinimide Antiabsence Drugs. Epilepsy Curr. 2:49-52. PMC320968 

75. Lin SH, Arai AC, España RA, Berridge CW, Leslie FM, Huguenard JR, Vergnes M, Civelli O (2002) Prolactin-releasing peptide (PrRP) promotes awakening and suppresses absence seizures. Neuroscience. 114:229-38.  

74. Kumar SS, Bacci A, Kharazia V, Huguenard JR (2002) A developmental switch of AMPA receptor subunits in neocortical pyramidal neurons. J Neurosci. 22:3005-15.  

73. Xiang Z, Huguenard JR, Prince DA (2002) Synaptic inhibition of pyramidal cells evoked by different interneuronal subtypes in layer v of rat visual cortex. J Neurophysiol. 88:740-50.  F1000 

72. Porcello DM, Ho CS, Joho RH, Huguenard JR (2002) Resilient RTN fast spiking in Kv3.1 null mice suggests redundancy in the action potential repolarization mechanism. J Neurophysiol. 87:1303-10.  

71. Huguenard JR (2002) Sodium channels: grit, determination, and persistence. Neuron. 33:492-4.  

70. Huguenard J (2001) Thalamocortical Circuits and Excitability. Epilepsy Curr. 1:13. PMC320682 

69. Sohal VS, Huguenard JR (2001) Clonazepam suppresses oscillations in rat thalamic slices Neurocomputing. 38-40:907-913.  

68. Kumar SS, Huguenard JR (2001) Properties of excitatory synaptic connections mediated by the corpus callosum in the developing rat neocortex. J Neurophysiol. 86:2973-85.  

67. Browne SH, Kang J, Akk G, Chiang LW, Schulman H, Huguenard JR, Prince DA (2001) Kinetic and pharmacological properties of GABA(A) receptors in single thalamic neurons and GABA(A) subunit expression. J Neurophysiol. 86:2312-22.  

66. Jacobsen RB, Ulrich D, Huguenard JR (2001) GABA(B) and NMDA receptors contribute to spindle-like oscillations in rat thalamus in vitro. J Neurophysiol. 86:1365-75.  

65. Sohal VS, Huguenard JR (2001) It takes T to tango. Neuron. 31:3-4.  

64. Sun QQ, Akk G, Huguenard JR, Prince DA (2001) Differential regulation of GABA release and neuronal excitability mediated by neuropeptide Y1 and Y2 receptors in rat thalamic neurons. J Physiol. 531:81-94. PMC2278458 

63. Sun QQ, Huguenard JR, Prince DA (2001) Neuropeptide Y receptors differentially modulate G-protein-activated inwardly rectifying K+ channels and high-voltage-activated Ca2+ channels in rat thalamic neurons. J Physiol. 531:67-79. PMC2278450 

62. Destexhe A, Huguenard JR (2000) Nonlinear thermodynamic models of voltage-dependent currents. J Comput Neurosci. 9:259-70.  

61. Huguenard JR (2000) Circuit mechanisms of spike-wave discharge: are there similar underpinnings for centrotemporal spikes? Epilepsia. 41:1076-7.  

60. Huguenard JR (2000) Reliability of axonal propagation: the spike doesn’t stop here. Proc Natl Acad Sci U S A. 97:9349-50. PMC34025 

59. Sohal VS, Huntsman, MM, Huguenard JR (2000) Reciprocal inhibitory connections produce desynchronizing phase lags during intrathalamic oscillations Neurocomputing. 32: 509-516.  

58. Sohal VS, Huntsman MM, Huguenard JR (2000) Reciprocal inhibitory connections regulate the spatiotemporal properties of intrathalamic oscillations. J Neurosci. 20:1735-45.  

57. Huntsman MM, Huguenard JR (2000) Nucleus-specific differences in GABA(A)-receptor-mediated inhibition are enhanced during thalamic development. J Neurophysiol. 83:350-8.  

56. Kang J, Huguenard JR, Prince DA (2000) Voltage-gated potassium channels activated during action potentials in layer V neocortical pyramidal neurons. J Neurophysiol. 83:70-80.  

55. Sohal VS, Huguenard JR (1999) Long-range connections synchronize rather than spread intrathalamic oscillatory activity: Computational modeling and in vitro electrophysiology Neurocomputing. 26-27:525-531.  

54. Huguenard JR (1999) Neuronal circuitry of thalamocortical epilepsy and mechanisms of antiabsence drug action. Adv Neurol. 79:991-9.  

53. Huntsman MM, Porcello DM, Homanics GE, DeLorey TM, Huguenard JR (1999) Reciprocal inhibitory connections and network synchrony in the mammalian thalamus. Science. 283:541-3.  

52. Huguenard JR (1998) Low-voltage-activated (T-type) calcium-channel genes identified. Trends Neurosci. 21:451-2.  

51. Sohal VS, Huguenard JR (1998) Long-range connections synchronize rather than spread intrathalamic oscillations: computational modeling and in vitro electrophysiology. J Neurophysiol. 80:1736-51.  

50. Xiang Z, Huguenard JR, Prince DA (1998) Cholinergic switching within neocortical inhibitory networks. Science. 281:985-8.  

49. Huguenard JR (1998) Anatomical and physiological considerations in thalamic rhythm generation. J Sleep Res. 7 Suppl 1:24-9.  

48. Destexhe A, Neubig M, Ulrich D, Huguenard J (1998) Dendritic low-threshold calcium currents in thalamic relay cells. J Neurosci. 18:3574-88.  

47. Sohal VS, Cox CL, Huguenard JR (1998) Localization of CCK receptors in thalamic reticular neurons: a modeling study. J Neurophysiol. 79:2820-4.  

46. Bennett BD, Huguenard JR, Prince DA (1998) Adrenergic modulation of GABAA receptor-mediated inhibition in rat sensorimotor cortex. J Neurophysiol. 79:937-46.  

45. Xiang Z, Huguenard JR, Prince DA (1998) GABAA receptor-mediated currents in interneurons and pyramidal cells of rat visual cortex. J Physiol. 506 ( Pt 3):715-30. PMC2230760 

44. Zhang SJ, Huguenard JR, Prince DA (1997) GABAA receptor-mediated Cl- currents in rat thalamic reticular and relay neurons. J Neurophysiol. 78:2280-6.  

43. Ulrich D, Huguenard JR (1997) GABA(A)-receptor-mediated rebound burst firing and burst shunting in thalamus. J Neurophysiol. 78:1748-51.  

42. Cox CL, Huguenard JR, Prince DA (1997) Nucleus reticularis neurons mediate diverse inhibitory effects in thalamus. Proc Natl Acad Sci U S A. 94:8854-9. PMC23165 

41. Bennett BD, Huguenard JR, Prince DA (1997) Adrenoceptor-mediated elevation of ambient GABA levels activates presynaptic GABA(B) receptors in rat sensorimotor cortex. J Neurophysiol. 78:561-6.  

40. Ulrich D, Huguenard JR (1997) Nucleus-specific chloride homeostasis in rat thalamus. J Neurosci. 17:2348-54.  

39. Cox CL, Huguenard JR, Prince DA (1997) Peptidergic modulation of intrathalamic circuit activity in vitro: actions of cholecystokinin. J Neurosci. 17:70-82.  

38. Kang J, Huguenard JR, Prince DA (1996) Two types of BK channels in immature rat neocortical pyramidal neurons. J Neurophysiol. 76:4194-7.  

37. Ulrich D, Huguenard JR (1996) Gamma-aminobutyric acid type B receptor-dependent burst-firing in thalamic neurons: a dynamic clamp study. Proc Natl Acad Sci U S A. 93:13245-9. PMC24078 

36. Kang J, Huguenard JR, Prince DA (1996) Development of BK channels in neocortical pyramidal neurons. J Neurophysiol. 76:188-98.  

35. Ulrich D, Huguenard JR (1996) GABAB receptor-mediated responses in GABAergic projection neurones of rat nucleus reticularis thalami in vitro. J Physiol. 493 ( Pt 3):845-54. PMC1159030 

34. Cox CL, Huguenard JR, Prince DA (1996) Heterogeneous axonal arborizations of rat thalamic reticular neurons in the ventrobasal nucleus. J Comp Neurol. 366:416-30.  

33. Huguenard JR, Chung JM, Prince DA (1996) Excitability changes in thalamic and neocortical neurons after injury. Epilepsy Res Suppl. 12:129-35.  

32. Huguenard JR (1996) Low-threshold calcium currents in central nervous system neurons. Annu Rev Physiol. 58:329-48.  

31. Destexhe A, Contreras D, Steriade M, Sejnowski TJ, Huguenard JR (1996) In vivo, in vitro, and computational analysis of dendritic calcium currents in thalamic reticular neurons. J Neurosci. 16:169-85.  

30. Mainen ZF, Joerges J, Huguenard JR, Sejnowski TJ (1995) A model of spike initiation in neocortical pyramidal neurons. Neuron. 15:1427-39.  

29. Ulrich D, Huguenard JR (1995) Purinergic inhibition of GABA and glutamate release in the thalamus: implications for thalamic network activity. Neuron. 15:909-18.  

28. Cox CL, Huguenard JR, Prince DA (1995) Cholecystokinin depolarizes rat thalamic reticular neurons by suppressing a K+ conductance. J Neurophysiol. 74:990-1000.  

27. Huguenard JR, Prince DA (1994) Intrathalamic rhythmicity studied in vitro: nominal T-current modulation causes robust antioscillatory effects. J Neurosci. 14:5485-502.  

26. Huguenard JR, Prince DA (1994) Clonazepam suppresses GABAB-mediated inhibition in thalamic relay neurons through effects in nucleus reticularis. J Neurophysiol. 71:2576-81.  

25. McCormick DA, Wang Z, Huguenard J (1993) Neurotransmitter control of neocortical neuronal activity and excitability. Cereb Cortex. 3:387-98.  

24. Chung JM, Huguenard JR, Prince DA (1993) Transient enhancement of low-threshold calcium current in thalamic relay neurons after corticectomy. J Neurophysiol. 70:20-7.  

23. Huguenard JR, Gutnick MJ, Prince DA (1993) Transient Ca2+ currents in neurons isolated from rat lateral habenula. J Neurophysiol. 70:158-66.  

22. Huguenard JR, Prince DA (1992) A novel T-type current underlies prolonged Ca(2+)-dependent burst firing in GABAergic neurons of rat thalamic reticular nucleus. J Neurosci. 12:3804-17.  

21. McCormick DA, Huguenard JR (1992) A model of the electrophysiological properties of thalamocortical relay neurons. J Neurophysiol. 68:1384-400.  

20. Huguenard JR, McCormick DA (1992) Simulation of the currents involved in rhythmic oscillations in thalamic relay neurons. J Neurophysiol. 68:1373-83.  

19. Coulter DA, Huguenard JR, Prince DA (1991) Mechanism of block of thalamic T-type Ca2+ channels by petit mal anticonvulsants Exp. Brain Res.: Physiology, Pharmacology and Development of Epileptogenic Phenomena, M.R. Klee (ed.) Frankfurt, Series. 20: 201-204.  

18. Huguenard JR, Coulter DA, Prince DA (1991) Properties of the low-threshold calcium current in thalamic relay neurons: Recovery from inactivation in relation to the control of repetitive burst generation Exp. Brain Res.: Physiology, Pharmacology and Development of Epileptogenic Phenomena, M.R. Klee (ed.) Frankfurt, Series. 20: 39-43.  

17. Huguenard JR, Prince DA (1991) Slow inactivation of a TEA-sensitive K current in acutely isolated rat thalamic relay neurons. J Neurophysiol. 66:1316-28.  

16. Huguenard JR, Coulter DA, Prince DA (1991) A fast transient potassium current in thalamic relay neurons: kinetics of activation and inactivation. J Neurophysiol. 66:1304-15.  

15. Hamill OP, Huguenard JR, Prince DA (1991) Patch-clamp studies of voltage-gated currents in identified neurons of the rat cerebral cortex. Cereb Cortex. 1:48-61.  

14. Coulter DA, Huguenard JR, Prince DA (1990) Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction. Br J Pharmacol. 100:800-6. PMC1917607 

13. Coulter DA, Huguenard JR, Prince DA (1990) Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: GABA current blockade. Br J Pharmacol. 100:807-13. PMC1917578 

12. Coulter DA, Huguenard JR, Prince DA (1989) Calcium currents in rat thalamocortical relay neurones: kinetic properties of the transient, low-threshold current. J Physiol. 414:587-604. PMC1189159 

11. Coulter DA, Huguenard JR, Prince DA (1989) Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons. Ann Neurol. 25:582-93.  

10. Huguenard JR, Hamill OP, Prince DA (1989) Sodium channels in dendrites of rat cortical pyramidal neurons. Proc Natl Acad Sci U S A. 86:2473-7. PMC286935 

9. Coulter DA, Huguenard JR, Prince DA (1989) Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons. Neurosci Lett. 98:74-8.  

8. Shen JM, Huguenard JR, Kriegstein AR (1988) Development of GABA responsiveness in embryonic turtle cortical neurons. Neurosci Lett. 89:335-41.  

7. Huguenard JR, Hamill OP, Prince DA (1988) Developmental changes in Na+ conductances in rat neocortical neurons: appearance of a slowly inactivating component. J Neurophysiol. 59:778-95.  

6. Huguenard JR, Alger BE (1986) Whole-cell voltage-clamp study of the fading of GABA-activated currents in acutely dissociated hippocampal neurons. J Neurophysiol. 56:1-18.  

5. Lewis DV, Huguenard JR, Anderson WW, Wilson WA (1986) Membrane currents underlying bursting pacemaker activity and spike frequency adaptation in invertebrates. Adv Neurol. 44:235-61.  

4. Huguenard JR, Wilson WA (1985) Barbiturate-induced alterations in the kinetic parameters of slow outward current in Aplysia giant neurons. J Pharmacol Exp Ther. 234:821-9.  

3. Huguenard JR, Zbicz KL, Lewis DV, Evans GJ, Wilson WA (1985) The ionic mechanism of the slow outward current in Aplysia neurons. J Neurophysiol. 54:449-61.  

2. Huguenard JR, Wilson WA (1985) Suppression of repetitive firing of neurons by diphenylbarbituric acid. J Pharmacol Exp Ther. 232:228-31.  

1. Bartolome J, Huguenard J, Slotkin TA (1980) Role of ornithine decarboxylase in cardiac growth and hypertrophy. Science. 210:793-4.  

Preprints

  Go to Peer Reviewed

5. Christine Joy Liu, Jordan Sorokin, Surya Ganguli, John Huguenard (2020) An Evolving-Dynamic Network Activity Approach to Epileptic Seizure Prediction using Machine Learning BioRxiv. https://www.biorxiv.org/content/10.1101/2020.11.29.402461v1.  

4. Anna V. Elleman, Gabrielle Devienne, Christopher D. Makinson, Allison L. Haynes, John R. Huguenard,
Justin Du Bois (2020) Precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin BioRxiv. https://www.biorxiv.org/content/10.1101/2020.11.18.389130v1. Final published version, paper #193  

3. Juliet K Knowles, Caroline Soane, Eleanor Frost, Lydia T Tam, Danielle Fraga, Haojun Xu, Ankita Batra, Lijun Ni, Katlin Villar, Tristan Saucedo, John Huguenard, Michelle Monje (2020) Maladaptive myelination promotes epileptogenesis in absence epilepsy BioRxiv. https://www.biorxiv.org/content/10.1101/2020.08.20.260083v1. Final published version, paper #195  

2. Adam C Lu, Christine Kyuyoung Lee, Max Kleiman-Weiner, Brian Truong, Megan Wang, John R Huguenard, Mark P Beenhakkerre (2020) Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic network oscillations BioRxiv. https://www.biorxiv.org/content/10.1101/2020.06.02.129601v1. Final published version, paper #187  

1. Jordan M Sorokin, Alex H Williams, Surya Ganguli, John R Huguenard (2020) Thalamic activity patterns unfolding over multiple time scales predict seizure onset in absence epilepsy BioRxiv. https://www.biorxiv.org/content/10.1101/2020.03.04.976688v1.