{"id":15,"date":"2017-03-24T19:56:56","date_gmt":"2017-03-24T19:56:56","guid":{"rendered":"https:\/\/huguenard-lab.stanford.edu\/wp1\/?page_id=15"},"modified":"2017-03-29T01:45:49","modified_gmt":"2017-03-29T01:45:49","slug":"publications","status":"publish","type":"page","link":"https:\/\/huguenard-lab.stanford.edu\/wp1\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

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212. Lee D, Han KA, Jeong H, Ha GE, Lee H, Kim BS, Park C, Piao Y, Lee H, Kim J, Yoon TH, Kim S, Kim B, Shin J, Cho Y, Kang S, Park HE, Um JW, Sohn CH, Huguenard JR<\/B>, Ko J, Cheong E (2026) Juvenile-to-adult refinement of thalamic reticular circuits via LRRTM3 enables high-resolution sensory encoding. Neuron<\/i>. :. <\/a> <\/a><\/p>\n

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211. Devienne G, Vantomme G, Huguenard JR<\/B> (2025) Disrupted Development of the mPFC-Thalamic Circuit in Shank3(-\/-) mice, an autism-associated model. Mol Psychiatry<\/i>. :. <\/a> <\/a> SI<\/a><\/p>\n

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210. Jang SS, Takahashi F, Huguenard JR<\/B> (2025) Reticular thalamic hyperexcitability drives autism spectrum disorder behaviors in the Cntnap2 model of autism. Sci Adv<\/i>. 11:eadw4682. <\/a>PMC12366697<\/a> <\/a> SI<\/a><\/p>\n

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209. Jang SS, Agranonik N, Huguenard JR<\/B> (2025) Actions of the antiseizure drug carbamazepine in the thalamic reticular nucleus: Potential mechanism of aggravating absence seizures. Proc Natl Acad Sci U S A<\/i>. 122:e2500644122. <\/a> <\/a> SI<\/a><\/p>\n

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208. Hull JM, Huguenard JR<\/B> (2025) Rhythmic Quakes Shock the Cortical Focus Theory. Epilepsy Curr<\/i>. :15357597251314673. <\/a> <\/a><\/p>\n

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207. Gomez-Frittelli J, Devienne GF, Travis L, Kyloh MA, Duan X, Hibberd TJ, Spencer NJ, Huguenard JR<\/B>, Kaltschmidt JA (2025) Synaptic cell adhesion molecule Cdh6 identifies a class of sensory neurons with novel functions in colonic motility. Elife<\/i>. 13:. <\/a> <\/a><\/p>\n

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206. Vantomme G, Devienne G, Hull JM, Huguenard JR<\/B> (2025) The reuniens thalamus recruits recurrent excitation in the medial prefrontal cortex. Proc Natl Acad Sci U S A<\/i>. 122:e2500321122. <\/a> <\/a> SI<\/a><\/p>\n

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205. Kim JI, Miura Y, Li MY, Revah O, Selvaraj S, Birey F, Meng X, Thete MV, Pavlov SD, Andersen J, Pa?ca AM, Porteus MH, Huguenard JR<\/B>, Pa?ca SP (2024) Human assembloids reveal the consequences of CACNA1G gene variants in the thalamocortical pathway. Neuron<\/i>. 112:4048-4059.e7. <\/a> <\/a><\/p>\n

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204. Stieger JR, Pinheiro-Chagas P, Fang Y, Li J, Lusk Z, Perry CM, Girn M, Contreras D, Chen Q, Huguenard JR<\/B>, Spreng RN, Edlow BL, Wagner AD, Buch V, Parvizi J (2024) Cross-regional coordination of activity in the human brain during autobiographical self-referential processing. Proc Natl Acad Sci U S A<\/i>. 121:e2316021121. <\/a> <\/a><\/p>\n

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203. <\/B>eLife Editorial Leadership, eLife Senior Editors, eLife Early Career Advisory Group (2024) How and why eLife selects papers for peer review. Elife<\/i>. 13:e100571. <\/a> <\/a><\/p>\n

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202. Chen X, Birey F, Li MY, Revah O, Levy R, Thete MV, Reis N, Kaganovsky K, Onesto M, Sakai N, Hudacova Z, Hao J, Meng X, Nishino S, Huguenard J<\/B>, Pa?ca SP (2024) Antisense oligonucleotide therapeutic approach for Timothy syndrome. Nature<\/i>. 628:818-825. <\/a>PMC11043036<\/a>  ESI Highly Cited<\/B><\/I> <\/a><\/p>\n

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201. Huguenard<\/B>, JR (2023) Adult Gene Therapy for Epilepsy in a Model of Angelman Syndrome: Hope or Hype? Epilepsy Curr<\/i>. 23:312-314. <\/a>PMC10601042<\/a> <\/a><\/p>\n

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200. Hahn O, Foltz AG, Atkins M, Kedir B, Moran-Losada P, Guldner IH, Munson C, Kern F, P\u00e1lovics R, Lu N, Zhang H, Kaur A, Hull J, Huguenard JR<\/B>, Gr\u00f6nke S, Lehallier B, Partridge L, Keller A, Wyss-Coray T (2023) Atlas of the aging mouse brain reveals white matter as vulnerable foci. Cell<\/i>. 186:4117-4133. <\/a>PMC10528304<\/a> <\/a><\/p>\n

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199. Zhao ET, Hull JM, Mintz Hemed N, Ulu?an H, Bartram J, Zhang A, Wang P, Pham A, Ronchi S, Huguenard JR<\/B>, Hierlemann A, Melosh NA (2023) A CMOS-based highly scalable flexible neural electrode interface. Sci Adv<\/i>. 9:eadf9524. <\/a>PMC10246892<\/a> <\/a><\/p>\n

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198. Ferguson B, Glick C, Huguenard JR<\/B> (2023) Prefrontal PV interneurons facilitate attention and are linked to attentional dysfunction in a mouse model of absence epilepsy. Elife<\/i>. 12:e78349. <\/a>PMC10072875<\/a> <\/a><\/p>\n

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197. Chang YT, Kowalczyk M, Fogerson PM, Lee YJ, Haque M, Adams EL, Wang DC, DeNardo LA, Tessier-Lavigne M, Huguenard JR<\/B>, Luo L, Huang WH (2022) Loss of Rai1 enhances hippocampal excitability and epileptogenesis in mouse models of Smith-Magenis syndrome Proc Natl Acad Sci U S A<\/i>. 119:e2210122119. <\/a>PMC9618093<\/a> <\/a><\/p>\n

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196. Revah O, Gore F, Kelley KW, Andersen J, Sakai N, Chen X, Li MY, Birey F, Yang X, Saw NL, Baker SW, Amin ND, Kulkarni S, Mudipalli R, Cui B, Nishino S, Grant GA, Knowles JK, Shamloo M, Huguenard JR<\/B>, Deisseroth K, Pasca SP (2022) Maturation and circuit integration of transplanted human cortical organoids. Nature<\/i>. 610:319-326. <\/a>PMC9556304<\/a> F1000<\/a>  ESI Highly Cited<\/B><\/I>  ESI Hot Paper<\/B><\/I> <\/a><\/p>\n

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195. Knowles JK, Xu H, Soane C, Batra A, Saucedo T, Frost E, Tam LT, Fraga D, Ni L, Villar K, Talmi S, Huguenard JR<\/B>, Monje M (2022) Maladaptive myelination promotes generalized epilepsy progression. Nat Neurosci<\/i>. 25:596-606. <\/a>PMC9076538<\/a> F1000<\/a> <\/a><\/p>\n

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194. Elleman AV, Devienne G, Makinson CD, Haynes AL, Huguenard JR<\/B>, Du Bois J (2022) Author Correction: Precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin. Nat Commun<\/i>. 13:2277. <\/a>PMC9023579<\/a> <\/a><\/p>\n

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193. Elleman AV, Devienne G, Makinson CD, Haynes AL, Huguenard JR<\/B>, Du Bois J (2021) Precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin. Nat Commun<\/i>. 12:4171. <\/a>PMC9023579<\/a> F1000<\/a> <\/a><\/p>\n

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192. Pan Y, Hysinger JD, Barron T, Schindler NF, Cobb O, Guo X, Yal\u00c3\u00a7\u00c4\u00b1n B, Anastasaki C, Mulinyawe SB, Ponnuswami A, Scheaffer S, Ma Y, Chang KC, Xia X, Toonen JA, Lennon JJ, Gibson EM, Huguenard JR<\/B>, Liau LM, Goldberg JL, Monje M, Gutmann DH (2021) NF1 mutation drives neuronal activity-dependent initiation of optic glioma. Nature<\/i>. 594:277-282. <\/a>PMC8346229<\/a> <\/a><\/p>\n

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191. Gordon A, Yoon SJ, Tran SS, Makinson CD, Park JY, Andersen J, Valencia AM, Horvath S, Xiao X, Huguenard JR<\/B>, Pa\u00c8\u2122ca SP, Geschwind DH (2021) Long-term maturation of human cortical organoids matches key early postnatal transitions. Nat Neurosci<\/i>. 24:331-342. <\/a>PMC8109149<\/a> F1000<\/a> <\/a><\/p>\n

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190. Huguenard JR <\/B> (2020) Perspective: Is Cortical Hyperexcitability the Only Path to Generalized Absence Epilepsy? Epilepsy Curr<\/i>. 20:59S-61S. <\/a>PMC7726732<\/a> <\/a><\/p>\n

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189. Koster AK, Reese AL, Kuryshev Y, Wen X, McKiernan KA, Gray EE, Wu C, Huguenard JR<\/B>, Maduke M, Du Bois J (2020) Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel. Proc Natl Acad Sci U S A<\/i>. 117:32711-32721. <\/a>PMC7768775<\/a> <\/a> SI<\/a><\/p>\n

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188. Khan TA, Revah O, Gordon A, Yoon SJ, Krawisz AK, Goold C, Sun Y, Kim CH, Tian Y, Li MY, Schaepe JM, Ikeda K, Amin ND, Sakai N, Yazawa M, Kushan L, Nishino S, Porteus MH, Rapoport JL, Bernstein JA, O’Hara R, Bearden CE, Hallmayer JF, Huguenard JR<\/B>, Geschwin (2020) Neuronal defects in a human cellular model of 22q11.2 deletion syndrome. Nat Med<\/i>. 26:1888-1898. <\/a> PMC8525897<\/a> F1000<\/a> <\/a><\/p>\n

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187. Lu AC, Lee CK, Kleiman-Weiner M, Truong B, Wang M, Huguenard JR<\/B>, Beenhakker MP (2020) Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic oscillations. Elife<\/i>. 9:e59548. <\/a>PMC7529462<\/a> <\/a><\/p>\n

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186. Huguenard J<\/B> (2019) Current Controversy: Spikes, Bursts, and Synchrony in Generalized Absence Epilepsy: Unresolved Questions Regarding Thalamocortical Synchrony in Absence Epilepsy. Epilepsy Curr<\/i>. 19:105-111. <\/a>PMC6610415<\/a> <\/a><\/p>\n

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185. Marton RM, Miura Y, Sloan SA, Li Q, Revah O, Levy RJ, Huguenard JR<\/B>, Pa\u00c8\u2122ca SP (2019) Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures. Nat Neurosci<\/i>. 22:484-491. <\/a>PMC6788758<\/a>  ESI Highly Cited<\/B><\/I> <\/a><\/p>\n

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184. Yoon SJ, Elahi LS, Pa\u00c8\u2122ca AM, Marton RM, Gordon A, Revah O, Miura Y, Walczak EM, Holdgate GM, Fan HC, Huguenard JR<\/B>, Geschwind DH, Pa\u00c8\u2122ca SP (2019) Reliability of human cortical organoid generation. Nat Methods<\/i>. 16:75-78. <\/a>PMC6677388<\/a>  ESI Highly Cited<\/B><\/I> <\/a><\/p>\n

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183. Ha HTT, Leal-Ortiz S, Lalwani K, Kiyonaka S, Hamachi I, Mysore SP, Montgomery JM, Garner CC, Huguenard JR<\/B>, Kim SA (2018) Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons. Front Mol Neurosci<\/i>. 11:405. <\/a>PMC6256285<\/a> <\/a><\/p>\n

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182. Ren J, Friedmann D, Xiong J, Liu CD, Ferguson BR, Weerakkody T, DeLoach KE, Ran C, Pun A, Sun Y, Weissbourd B, Neve RL, Huguenard J<\/B>, Horowitz MA, Luo L (2018) Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems. Cell<\/i>. 175:1\u00e2\u20ac\u201c16. <\/a>PMC6173627<\/a> F1000<\/a> <\/a><\/p>\n

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181. Sorokin JM, Paz JT, Huguenard JR<\/B> (2017) Absence seizure susceptibility correlates with pre-ictal \u00ce\u00b2 oscillations. J Physiol Paris<\/i>. DOI:10.1016\/j.jphysparis.2017.05.004. <\/a>PMC5607110<\/a> <\/a><\/p>\n

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180. Birey F, Andersen J, Makinson CD, Islam S, Wei W, Huber N, Fan HC, Metzler KRC, Panagiotakos G, Thom N, O’Rourke NA, Steinmetz LM, Bernstein JA, Hallmayer J, Huguenard JR<\/B>, Pasca SP (2017) Assembly of functionally integrated human forebrain spheroids Nature<\/i>. doi:10.1038\/nature22047. <\/a>PMC5805137<\/a> F1000<\/a>  ESI Highly Cited<\/B><\/I>  ESI Hot Paper<\/B><\/I> <\/a><\/p>\n

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179. Yackle K, Schwarz LA, Kam K, Sorokin JM, Huguenard JR<\/B>, Feldman JL, Luo L, Krasnow MA (2017) Breathing control center neurons that promote arousal in mice. Science<\/i>. 355:1411-1415. <\/a> PMC5505554 <\/a> F1000<\/a> <\/a><\/p>\n

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178. Makinson CD, Tanaka BS, Sorokin JM, Wong JC, Christian CA, Goldin AL, Escayg A, Huguenard JR<\/B> (2017) Regulation of Thalamic and Cortical Network Synchrony by Scn8a. Neuron<\/i>. 93:1165-1179. <\/a> PMC5393918<\/a> F1000<\/a> <\/a> SI<\/a><\/p>\n

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177. Sorokin JM, Davidson TJ, Frechette E, Abramian AM, Deisseroth K, Huguenard JR<\/B>, Paz JT (2017) Bidirectional Control of Generalized Epilepsy Networks via Rapid Real-Time Switching of Firing Mode. Neuron<\/i>. 93:194-210. <\/a>PMC5268077<\/a>  ESI Highly Cited<\/B><\/I> <\/a><\/p>\n

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176. Fogerson PM, Huguenard JR<\/B> (2016) Tapping the Brakes: Cellular and Synaptic Mechanisms that Regulate Thalamic Oscillations. Neuron<\/i>. 92:687-704. <\/a>PMC5131525<\/a> <\/a><\/p>\n

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175. Fogerson PM, Huguenard JR<\/B> (2016) Catching a wave. Elife<\/i>. 5:pii: e21236. <\/a>PMC5059133<\/a> <\/a><\/p>\n

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174. Brill J, Mattis J, Deisseroth K, Huguenard JR<\/B> (2016) LSPS\/Optogenetics to Improve Synaptic Connectivity Mapping: Unmasking the Role of Basket Cell-Mediated Feedforward Inhibition. eNeuro<\/i>. 3:pii: ENEURO.0142-15.2016. <\/a>PMC4976301<\/a> <\/a><\/p>\n

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173. Deleuze C, Huguenard JR<\/B> (2016) Two classes of excitatory synaptic responses in rat thalamic reticular neurons. J Neurophysiol<\/i>. 116:995-1011. <\/a>PMC5009213<\/a> <\/a><\/p>\n

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172. Ha H, Huguenard J<\/B> (2016) Criminal Minds: Cav3.2 Channels Are the Culprits, but NMDAR Are the Co-Conspirators. Epilepsy Curr<\/i>. 16:36-8. <\/a>PMC4749115<\/a> <\/a><\/p>\n

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171. Hiu T, Farzampour Z, Paz JT, Wang EH, Badgely C, Olson A, Micheva KD, Wang G, Lemmens R, Tran KV, Nishiyama Y, Liang X, Hamilton SA, O’Rourke N, Smith SJ, Huguenard JR<\/B>, Bliss TM, Steinberg GK (2016) Enhanced phasic GABA inhibition during the repair phase of stroke: a novel therapeutic target. Brain<\/i>. 139:468-80. <\/a>PMC4805083<\/a> <\/a><\/p>\n

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170. Pangratz-Fuehrer S, Sieghart W, Rudolph U, Parada I, Huguenard JR<\/B> (2016) Early Postnatal Switch in GABAAR \u00ce\u00b1 Subunits in the Reticular Thalamic Nucleus. J Neurophysiol<\/i>. 115:1183-1195. <\/a>PMC4808120<\/a> <\/a><\/p>\n

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169. Adamantidis A, Arber S, Bains JS, Bamberg E, Bonci A, Buzs\u00c3\u00a1ki G, Cardin JA, Costa RM, Dan Y, Goda Y, Graybiel AM, H\u00c3\u00a4usser M, Hegemann P, Huguenard JR<\/B>, Insel TR, Janak PH, Johnston D, Josselyn SA, Koch C, Kreitzer AC, L\u00c3\u00bcscher C, Malenka RC, Miesenb\u00c3\u00b6ck (2015) Optogenetics: 10 years after ChR2 in neurons-views from the community. Nat Neurosci<\/i>. 18:1202-1212. <\/a>PMC4489980<\/a> <\/a><\/p>\n

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168. Pa\u00c5\u0178ca AM, Sloan SA, Clarke LE, Tian Y, Makinson CD, Huber N, Kim CH, Park JY, O’Rourke NA, Nguyen KD, Smith SJ, Huguenard JR<\/B>, Geschwind DH, Barres BA, Pa\u00c5\u0178ca SP (2015) Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture. Nat Methods<\/i>. 12:671-8. <\/a>PMC4489980<\/a> F1000<\/a>  ESI Highly Cited<\/B><\/I>  ESI Hot Paper<\/B><\/I> <\/a><\/p>\n

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167. Weissberg I, Wood L, Kamintsky L, Vazquez O, Milikovsky DZ, Alexander A, Oppenheim H, Ardizzone C, Becker A, Frigerio F, Vezzani A, Buckwalter MS, Huguenard J<\/B>, Friedman A, Kaufer D (2015) Albumin induces excitatory synaptogenesis through astrocytic TGF-\u00ce\u00b2\/ALK5 signaling in a model of acquired epilepsy following blood-brain barrier dysfunction. Neurobiol Dis<\/i>. 78:115-125. <\/a>PMC4426044<\/a> <\/a><\/p>\n

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166. Ma Y, Juntti SA, Hu CK, Huguenard JR<\/B>, Fernald RD (2015) Electrical synapses connect a network of gonadotropin releasing hormone neurons in a cichlid fish. Proc Natl Acad Sci U S A<\/i>. 112:3805-10. <\/a>PMC4378424<\/a> F1000<\/a> <\/a><\/p>\n

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165. Paz JT, Huguenard JR<\/B> (2015) Microcircuits and their interactions in epilepsy: is the focus out of focus? Nat Neurosci<\/i>. 18:351-359. <\/a>PMC4561622<\/a>  ESI Highly Cited<\/B><\/I> <\/a><\/p>\n

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164. Paz JT, Huguenard JR<\/B> (2015) Optogenetics and epilepsy: past, present and future. Epilepsy Curr<\/i>. 15:34-8. <\/a>PMC4320957<\/a> <\/a><\/p>\n

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163. Farzampour Z, Huguenard J<\/B> (2015) Seizing upon Mechanisms for Impaired Consciousness. Neuron<\/i>. 85:453-5. <\/a>PMC4554486<\/a> <\/a><\/p>\n

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162. Farzampour Z, Reimer RJ, Huguenard J<\/B> (2015) Endozepines. Adv Pharmacol<\/i>. 72:147-64. <\/a>PMC4550098<\/a> <\/a><\/p>\n

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161. Bryant AS, Goddard CA, Huguenard JR<\/B>, Knudsen EI (2015) Cholinergic control of gamma power in the midbrain spatial attention network. J Neurosci<\/i>. 35:761-75. <\/a>PMC4293421<\/a> <\/a><\/p>\n

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160. Makinson CD, Huguenard JR<\/B> (2015) Attentional flexibility in the thalamus: now we’re getting SOMwhere. Nat Neurosci<\/i>. 18:2-4. <\/a>PMC4556356<\/a> <\/a><\/p>\n

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159. Leone DP, Heavner WE, Ferenczi EA, Dobreva G, Huguenard JR<\/B>, Grosschedl R, McConnell SK (2015) Satb2 Regulates the Differentiation of Both Callosal and Subcerebral Projection Neurons in the Developing Cerebral Cortex. Cereb Cortex<\/i>. 25:3406-19. <\/a>PMC4585495<\/a> <\/a><\/p>\n

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158. Mattis J, Brill J, Evans S, Lerner TN, Davidson TJ, Hyun M, Ramakrishnan C, Deisseroth K, Huguenard JR<\/B> (2014) Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection. J Neurosci<\/i>. 34:11769-80. <\/a>PMC4145178<\/a> <\/a><\/p>\n

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157. Goddard CA, Huguenard J<\/B>, Knudsen E (2014) Parallel midbrain microcircuits perform independent temporal transformations. J Neurosci<\/i>. 34:8130-8. <\/a>PMC4051971<\/a> <\/a><\/p>\n

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156. Tani H, Dulla CG, Farzampour Z, Taylor-Weiner A, Huguenard JR<\/B>, Reimer RJ (2014) A local glutamate-glutamine cycle sustains synaptic excitatory transmitter release. Neuron<\/i>. 81:888-900. <\/a>PMC4001919<\/a> F1000<\/a> <\/a><\/p>\n

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155. Goddard CA, Mysore SP, Bryant AS, Huguenard JR<\/B>, Knudsen EI (2014) Spatially Reciprocal Inhibition of Inhibition within a Stimulus Selection Network in the Avian Midbrain. PLoS One<\/i>. 9:e85865. <\/a>PMC3897538<\/a> <\/a><\/p>\n

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154. Kyuyoung CL, Huguenard JR<\/B> (2014) Modulation of short-term plasticity in the corticothalamic circuit by group III metabotropic glutamate receptors. J Neurosci<\/i>. 34:675-87. <\/a>PMC3870944<\/a> <\/a><\/p>\n

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153. Christian CA, Huguenard JR<\/B> (2013) Astrocytes potentiate GABAergic transmission in the thalamic reticular nucleus via endozepine signaling. Proc Natl Acad Sci U S A<\/i>. 110:20278-83. <\/a>PMC3864346<\/a> <\/a><\/p>\n

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152. Christian CA, Huguenard JR<\/B> (2013) Sniffer Patch Laser Uncaging REsponse (SPLURgE): an assay of regional differences in allosteric receptor modulation and neurotransmitter clearance. J Neurophysiol<\/i>. 110:1722-31. <\/a>PMC4042414<\/a> <\/a><\/p>\n

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151. Christian CA, Herbert AG, Holt RL, Peng K, Sherwood KD, Pangratz-Fuehrer S, Rudolph U, Huguenard JR<\/B> (2013) Endogenous Positive Allosteric Modulation of GABAA Receptors by Diazepam binding inhibitor. Neuron<\/i>. 78:1063-74. <\/a>PMC3987987<\/a> F1000<\/a> <\/a><\/p>\n

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150. Dewolfe JL, Malow B, Huguenard J<\/B>, Stickgold R, Bourgeois B, Holmes GL (2013) Sleep and epilepsy: a summary of the 2011 merritt-putnam symposium. Epilepsy Curr<\/i>. 13:42-9. <\/a>PMC3577087<\/a> <\/a><\/p>\n

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149. Ma Y, Huguenard JR<\/B> (2013) Reemerging role of cable properties in action potential initiation. Proc Natl Acad Sci U S A<\/i>. 110:3715-6. <\/a>PMC3593907<\/a> <\/a><\/p>\n

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148. Paz JT, Davidson TJ, Frechette ES, Delord B, Parada I, Peng K, Deisseroth K, Huguenard JR<\/B> (2013) Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury. Nat Neurosci<\/i>. 16:64-70. <\/a>PMC3700812<\/a> F1000<\/a>  ESI Highly Cited<\/B><\/I> <\/a><\/p>\n

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147. Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, Gross RA, Gubitz AK, Hesterlee SE, Howells DW, Huguenard J<\/B>, Kelner K, Koro (2012) A call for transparent reporting to optimize the predictive value of preclinical research. Nature<\/i>. 490:187-91. <\/a>PMC3511845<\/a>  ESI Highly Cited<\/B><\/I> <\/a><\/p>\n

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146. Dulla CG, Tani H, Brill J, Reimer RJ, Huguenard JR<\/B> (2012) Glutamate biosensor imaging reveals dysregulation of glutamatergic pathways in a model of developmental cortical malformation. Neurobiol Dis<\/i>. 49C:232-246. <\/a>PMC3574209<\/a> <\/a><\/p>\n

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145. Carter ME, Brill J, Bonnavion P, Huguenard JR<\/B>, Huerta R, de Lecea L (2012) Mechanism for Hypocretin-mediated sleep-to-wake transitions. Proc Natl Acad Sci U S A<\/i>. 109:E2635-44. <\/a>PMC3465396<\/a> <\/a><\/p>\n

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144. Lacey CJ, Bryant A, Brill J, Huguenard JR<\/B> (2012) Enhanced NMDA receptor-dependent thalamic excitation and network oscillations in stargazer mice. J Neurosci<\/i>. 32:11067-81. <\/a>PMC3430525<\/a> <\/a><\/p>\n

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143. Paz JT, Huguenard JR<\/B> (2012) R U OK? The Novel Therapeutic Potential of R Channels in Epilepsy. Epilepsy Curr<\/i>. 12:75-6. <\/a>PMC3316366<\/a> <\/a><\/p>\n

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142. Goddard CA, Sridharan D, Huguenard JR<\/B>, Knudsen EI (2012) Gamma oscillations are generated locally in an attention-related midbrain network. Neuron<\/i>. 73:567-80. <\/a>PMC3291715<\/a> <\/a><\/p>\n

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141. Zhang W, Huguenard JR<\/B>, Buckmaster PS (2012) Increased excitatory synaptic input to granule cells from hilar and CA3 regions in a rat model of temporal lobe epilepsy. J Neurosci<\/i>. 32:1183-96. <\/a>PMC3778651<\/a> <\/a><\/p>\n

<\/div>\n

140. Paz JT, Bryant AS, Peng K, Fenno L, Yizhar O, Frankel WN, Deisseroth K, Huguenard JR<\/B> (2011) A new mode of corticothalamic transmission revealed in the Gria4(-\/-) model of absence epilepsy. Nat Neurosci<\/i>. 14:1167-73. <\/a>PMC3308017<\/a> <\/a> SI<\/a><\/p>\n

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139. Yizhar O, Fenno LE, Prigge M, Schneider F, Davidson TJ, O’Shea DJ, Sohal VS, Goshen I, Finkelstein J, Paz JT, Stehfest K, Fudim R, Ramakrishnan C, Huguenard JR<\/B>, Hegemann P, Deisseroth K (2011) Neocortical excitation\/inhibition balance in information processing and social dysfunction. Nature<\/i>. 477:171-8. <\/a>PMC4155501<\/a> F1000<\/a>  ESI Highly Cited<\/B><\/I> <\/a> SI<\/a><\/p>\n

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138. Mao R, Schummers J, Knoblich U, Lacey CJ, Van Wart A, Cobos I, Kim C, Huguenard JR<\/B>, Rubenstein JL, Sur M (2011) Influence of a Subtype of Inhibitory Interneuron on Stimulus-Specific Responses in Visual Cortex. Cereb Cortex<\/i>. 22:493-508. <\/a>PMC3278313<\/a> <\/a><\/p>\n

<\/div>\n

137. Lee CK, Huguenard JR<\/B> (2011) Martinotti cells: community organizers. Neuron<\/i>. 69:1042-5. <\/a>PMC3068616<\/a> <\/a><\/p>\n

<\/div>\n

136. Beenhakker MP, Huguenard JR<\/B> (2010) Astrocytes as gatekeepers of GABAB receptor function. J Neurosci<\/i>. 30:15262-76. <\/a>PMC3056552<\/a> <\/a><\/p>\n

<\/div>\n

135. Manseau F, Marinelli S, M\u00c3\u00a9ndez P, Schwaller B, Prince DA, Huguenard JR<\/B>, Bacci A (2010) Desynchronization of neocortical networks by asynchronous release of GABA at autaptic and synaptic contacts from fast-spiking interneurons. PLoS Biol<\/i>. 8:. <\/a>PMC2946936<\/a> <\/a><\/p>\n

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134. Jin X, Huguenard JR<\/B>, Prince DA (2011) Reorganization of inhibitory synaptic circuits in rodent chronically injured epileptogenic neocortex. Cereb Cortex<\/i>. 21:1094-104. <\/a>PMC3077430<\/a> <\/a><\/p>\n

<\/div>\n

133. Anderson TR, Huguenard JR<\/B>, Prince DA (2010) Differential effects of Na+-K+ ATPase blockade on cortical layer V neurons. J Physiol<\/i>. 588:4401-14. <\/a>PMC3008847<\/a> <\/a><\/p>\n

<\/div>\n

132. Paz JT, Christian CA, Parada I, Prince DA, Huguenard JR<\/B> (2010) Focal cortical infarcts alter intrinsic excitability and synaptic excitation in the reticular thalamic nucleus. J Neurosci<\/i>. 30:5465-79. <\/a>PMC2861582<\/a> <\/a><\/p>\n

<\/div>\n

131. Brill J, Huguenard JR<\/B> (2010) Enhanced infragranular and supragranular synaptic input onto layer 5 pyramidal neurons in a rat model of cortical dysplasia. Cereb Cortex<\/i>. 20:2926-38. <\/a>PMC3003588<\/a> <\/a><\/p>\n

<\/div>\n

130. Tani H, Dulla CG, Huguenard JR<\/B>, Reimer RJ (2010) Glutamine is required for persistent epileptiform activity in the disinhibited neocortical brain slice. J Neurosci<\/i>. 30:1288-300. <\/a>PMC2821093<\/a> <\/a><\/p>\n

<\/div>\n

129. Mignot E, Huguenard JR<\/B> (2009) Resting our cortices by going DOWN to sleep. Neuron<\/i>. 63:719-21. <\/a> <\/a><\/p>\n

<\/div>\n

128. Bryant AS, Li B, Beenhakker MP, Huguenard JR<\/B> (2009) Maintenance of thalamic epileptiform activity depends on the astrocytic glutamate-glutamine cycle. J Neurophysiol<\/i>. 102:2880-8. <\/a>PMC2777838<\/a> <\/a><\/p>\n

<\/div>\n

127. Dulla CG, Huguenard JR<\/B> (2009) Who let the spikes out? Nat Neurosci<\/i>. 12:959-60. <\/a>PMC2907263<\/a> <\/a><\/p>\n

<\/div>\n

126. Beenhakker MP, Huguenard JR<\/B> (2009) Neurons that fire together also conspire together: is normal sleep circuitry hijacked to generate epilepsy? Neuron<\/i>. 62:612-32. <\/a>PMC2748990<\/a> <\/a><\/p>\n

<\/div>\n

125. Brill J, Huguenard JR<\/B> (2009) Robust short-latency perisomatic inhibition onto neocortical pyramidal cells detected by laser-scanning photostimulation. J Neurosci<\/i>. 29:7413-23. <\/a>PMC2797487<\/a> F1000<\/a> <\/a><\/p>\n

<\/div>\n

124. Kleiman-Weiner M, Beenhakker MP, Segal WA, Huguenard JR<\/B> (2009) Synergistic roles of GABAA receptors and SK channels in regulating thalamocortical oscillations. J Neurophysiol<\/i>. 102:203-13. <\/a>PMC2712277<\/a> <\/a><\/p>\n

<\/div>\n

123. Schofield CM, Kleiman-Weiner M, Rudolph U, Huguenard JR<\/B> (2009) A gain in GABAA receptor synaptic strength in thalamus reduces oscillatory activity and absence seizures. Proc Natl Acad Sci U S A<\/i>. 106:7630-5. <\/a>PMC2678654<\/a> <\/a><\/p>\n

<\/div>\n

122. Brill J, Huguenard JR<\/B> (2008) Sequential changes in AMPA receptor targeting in the developing neocortical excitatory circuit. J Neurosci<\/i>. 28:13918-28. <\/a>PMC2706010<\/a> <\/a><\/p>\n

<\/div>\n

121. Marinelli S, Pacioni S, Bisogno T, Di Marzo V, Prince DA, Huguenard JR<\/B>, Bacci A (2008) The endocannabinoid 2-arachidonoylglycerol is responsible for the slow self-inhibition in neocortical interneurons. J Neurosci<\/i>. 28:13532-41. <\/a>PMC2615383<\/a> <\/a><\/p>\n

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120. Winsky-Sommerer R, Knapman A, Fedele DE, Schofield CM, Vyazovskiy VV, Rudolph U, Huguenard JR<\/B>, Fritschy JM, Tobler I (2008) Normal sleep homeostasis and lack of epilepsy phenotype in GABA A receptor alpha3 subunit-knockout mice. Neuroscience<\/i>. 154:595-605. <\/a>PMC2587445<\/a> <\/a><\/p>\n

<\/div>\n

119. Beyer B, Deleuze C, Letts VA, Mahaffey CL, Boumil RM, Lew TA, Huguenard JR<\/B>, Frankel WN (2008) Absence seizures in C3H\/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4. Hum Mol Genet<\/i>. 17:1738-49. <\/a>PMC2405903<\/a> <\/a><\/p>\n

<\/div>\n

118. Yue BW, Huguenard JR<\/B> (2001) The role of H-current in regulating strength and frequency of thalamic network oscillations. Thalamus Relat Syst<\/i>. 1:95-103. <\/a>PMC2222919<\/a> <\/a><\/p>\n

<\/div>\n

117. Sun QQ, Huguenard JR<\/B>, Prince DA (2005) Reorganization of barrel circuits leads to thalamically-evoked cortical epileptiform activity. Thalamus Relat Syst<\/i>. 3:261-273. <\/a>PMC2184932<\/a> <\/a><\/p>\n

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116. Dulla C, Tani H, Okumoto S, Frommer WB, Reimer RJ, Huguenard JR<\/B> (2008) Imaging of glutamate in brain slices using FRET sensors. J Neurosci Methods<\/i>. 168:306-19. <\/a>PMC2267481<\/a> <\/a><\/p>\n

<\/div>\n

115. Goddard CA, Knudsen EI, Huguenard JR<\/B> (2007) Intrinsic excitability of cholinergic neurons in the rat parabigeminal nucleus. J Neurophysiol<\/i>. 98:3486-93. <\/a> <\/a><\/p>\n

<\/div>\n

114. Schofield CM, Huguenard JR<\/B> (2007) GABA affinity shapes IPSCs in thalamic nuclei. J Neurosci<\/i>. 27:7954-62. <\/a> <\/a><\/p>\n

<\/div>\n

113. Huguenard JR<\/B>, McCormick DA (2007) Thalamic synchrony and dynamic regulation of global forebrain oscillations. Trends Neurosci<\/i>. 30:350-6. <\/a> <\/a><\/p>\n

<\/div>\n

112. Shin J, Shen F, Huguenard J<\/B> (2007) PKC and polyamine modulation of GluR2-deficient AMPA receptors in immature neocortical pyramidal neurons of the rat. J Physiol<\/i>. 581:679-91. <\/a>PMC2075192<\/a> <\/a><\/p>\n

<\/div>\n

111. Kumar SS, Jin X, Buckmaster PS, Huguenard JR<\/B> (2007) Recurrent circuits in layer II of medial entorhinal cortex in a model of temporal lobe epilepsy. J Neurosci<\/i>. 27:1239-46. <\/a> <\/a><\/p>\n

<\/div>\n

110. Staley KJ, Huguenard JR<\/B> (2006) A thalamic sleep tonic. Epilepsy Curr<\/i>. 6:164-6. <\/a>PMC1783475<\/a> <\/a><\/p>\n

<\/div>\n

109. Pangratz-Fuehrer S, Rudolph U, Huguenard JR<\/B> (2007) Giant spontaneous depolarizing potentials in the developing thalamic reticular nucleus. J Neurophysiol<\/i>. 97:2364-72. <\/a> <\/a><\/p>\n

<\/div>\n

108. Li H, Huguenard JR<\/B>, Fisher RS (2007) Gender and age differences in expression of GABAA receptor subunits in rat somatosensory thalamus and cortex in an absence epilepsy model. Neurobiol Dis<\/i>. 25:623-30. <\/a>PMC2708099<\/a> <\/a><\/p>\n

<\/div>\n

107. Brill J, Kwakye G, Huguenard JR<\/B> (2007) NPY signaling through Y1 receptors modulates thalamic oscillations. Peptides<\/i>. 28:250-6. <\/a>PMC1945169<\/a> <\/a><\/p>\n

<\/div>\n

106. Tani H, Bandrowski AE, Parada I, Wynn M, Huguenard JR<\/B>, Prince DA, Reimer RJ (2007) Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsy. Neurobiol Dis<\/i>. 25:230-8. <\/a>PMC1952182<\/a> <\/a><\/p>\n

<\/div>\n

105. Deleuze C, Huguenard JR<\/B> (2006) Distinct electrical and chemical connectivity maps in the thalamic reticular nucleus: potential roles in synchronization and sensation. J Neurosci<\/i>. 26:8633-45. <\/a> F1000<\/a> <\/a> SI<\/a><\/p>\n

<\/div>\n

104. Brill J, Lee M, Zhao S, Fernald RD, Huguenard JR<\/B> (2006) Chronic valproic acid treatment triggers increased neuropeptide y expression and signaling in rat nucleus reticularis thalami. J Neurosci<\/i>. 26:6813-22. <\/a> <\/a><\/p>\n

<\/div>\n

103. Halabisky B, Shen F, Huguenard JR<\/B>, Prince DA (2006) Electrophysiological classification of somatostatin-positive interneurons in mouse sensorimotor cortex. J Neurophysiol<\/i>. 96:834-45. <\/a> <\/a><\/p>\n

<\/div>\n

102. Li H, Kraus A, Wu J, Huguenard JR<\/B>, Fisher RS (2006) Selective changes in thalamic and cortical GABAA receptor subunits in a model of acquired absence epilepsy in the rat. Neuropharmacology<\/i>. 51:121-8. <\/a> <\/a><\/p>\n

<\/div>\n

101. Jin X, Prince DA, Huguenard JR<\/B> (2006) Enhanced excitatory synaptic connectivity in layer v pyramidal neurons of chronically injured epileptogenic neocortex in rats. J Neurosci<\/i>. 26:4891-900. <\/a> <\/a><\/p>\n

<\/div>\n

100. Sohal VS, Pangratz-Fuehrer S, Rudolph U, Huguenard JR<\/B> (2006) Intrinsic and synaptic dynamics interact to generate emergent patterns of rhythmic bursting in thalamocortical neurons. J Neurosci<\/i>. 26:4247-55. <\/a> <\/a><\/p>\n

<\/div>\n

99. Huntsman MM, Huguenard JR<\/B> (2006) Fast IPSCs in rat thalamic reticular nucleus require the GABAA receptor beta1 subunit. J Physiol<\/i>. 572:459-75. <\/a>PMC1779681<\/a> <\/a><\/p>\n

<\/div>\n

98. Sun QQ, Huguenard JR<\/B>, Prince DA (2006) Barrel cortex microcircuits: thalamocortical feedforward inhibition in spiny stellate cells is mediated by a small number of fast-spiking interneurons. J Neurosci<\/i>. 26:1219-30. <\/a> <\/a><\/p>\n

<\/div>\n

97. Bacci A, Huguenard JR<\/B> (2006) Enhancement of spike-timing precision by autaptic transmission in neocortical inhibitory interneurons. Neuron<\/i>. 49:119-30. <\/a> F1000<\/a> <\/a><\/p>\n

<\/div>\n

96. Sohal VS, Huguenard JR<\/B> (2005) Inhibitory coupling specifically generates emergent gamma oscillations in diverse cell types. Proc Natl Acad Sci U S A<\/i>. 102:18638-43. <\/a>PMC1317969<\/a> <\/a><\/p>\n

<\/div>\n

95. Bacci A, Huguenard JR<\/B>, Prince DA (2005) Modulation of neocortical interneurons: extrinsic influences and exercises in self-control. Trends Neurosci<\/i>. 28:602-10. <\/a> <\/a><\/p>\n

<\/div>\n

94. Jin X, Huguenard JR<\/B>, Prince DA (2005) Impaired Cl- extrusion in layer V pyramidal neurons of chronically injured epileptogenic neocortex. J Neurophysiol<\/i>. 93:2117-26. <\/a> <\/a><\/p>\n

<\/div>\n

93. Shin J, Shen F, Huguenard JR<\/B> (2005) Polyamines modulate AMPA receptor-dependent synaptic responses in immature layer v pyramidal neurons. J Neurophysiol<\/i>. 93:2634-43. <\/a> <\/a><\/p>\n

<\/div>\n

92. Bacci A, Huguenard JR<\/B>, Prince DA (2004) Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids. Nature<\/i>. 431:312-6. <\/a> F1000<\/a> <\/a><\/p>\n

<\/div>\n

91. Huguenard JR<\/B> (2004) T-Channel Defects in Patients with Childhood Absence Epilepsy. Epilepsy Curr<\/i>. 4:7-8. <\/a>PMC324574<\/a> <\/a><\/p>\n

<\/div>\n

90. Kumar SS, Huguenard JR<\/B> (2003) Pathway-specific differences in subunit composition of synaptic NMDA receptors on pyramidal neurons in neocortex. J Neurosci<\/i>. 23:10074-83. <\/a> F1000<\/a> <\/a><\/p>\n

<\/div>\n

89. Huguenard J<\/B> (2003) Neurotransmitter Supply and Demand in Epilepsy. Epilepsy Curr<\/i>. 3:61-63. <\/a>PMC321172<\/a> <\/a><\/p>\n

<\/div>\n

88. Bacci A, Rudolph U, Huguenard JR<\/B>, Prince DA (2003) Major differences in inhibitory synaptic transmission onto two neocortical interneuron subclasses. J Neurosci<\/i>. 23:9664-74. <\/a> <\/a><\/p>\n

<\/div>\n

87. Sun QQ, Baraban SC, Prince DA, Huguenard JR<\/B> (2003) Target-specific neuropeptide Y-ergic synaptic inhibition and its network consequences within the mammalian thalamus. J Neurosci<\/i>. 23:9639-49. <\/a> <\/a><\/p>\n

<\/div>\n

86. Sohal VS, Huguenard JR<\/B> (2003) Inhibitory interconnections control burst pattern and emergent network synchrony in reticular thalamus. J Neurosci<\/i>. 23:8978-88. <\/a> <\/a><\/p>\n

<\/div>\n

85. Sohal VS, Keist R, Rudolph U, Huguenard JR<\/B> (2003) Dynamic GABA(A) receptor subtype-specific modulation of the synchrony and duration of thalamic oscillations. J Neurosci<\/i>. 23:3649-57. <\/a> <\/a><\/p>\n

<\/div>\n

84. Sun QQ, Prince DA, Huguenard JR<\/B> (2003) Vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide activate hyperpolarization-activated cationic current and depolarize thalamocortical neurons in vitro. J Neurosci<\/i>. 23:2751-8. <\/a> <\/a><\/p>\n

<\/div>\n

83. Bandrowski AE, Huguenard JR<\/B>, Prince DA (2003) Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex. J Neurophysiol<\/i>. 89:1308-16. <\/a>PMC3005275<\/a> <\/a><\/p>\n

<\/div>\n

82. Bacci A, Huguenard JR<\/B>, Prince DA (2003) Functional autaptic neurotransmission in fast-spiking interneurons: a novel form of feedback inhibition in the neocortex. J Neurosci<\/i>. 23:859-66. <\/a> F1000<\/a> <\/a><\/p>\n

<\/div>\n

81. Porcello DM, Smith SD, Huguenard JR<\/B> (2003) Actions of U-92032, a T-type Ca2+ channel antagonist, support a functional linkage between I(T) and slow intrathalamic rhythms. J Neurophysiol<\/i>. 89:177-85. <\/a> <\/a><\/p>\n

<\/div>\n

80. Porcello DM, Huntsman MM, Mihalek RM, Homanics GE, Huguenard JR<\/B> (2003) Intact synaptic GABAergic inhibition and altered neurosteroid modulation of thalamic relay neurons in mice lacking delta subunit. J Neurophysiol<\/i>. 89:1378-86. <\/a> <\/a><\/p>\n

<\/div>\n

79. Sohal VS, Huguenard JR<\/B> (2002) Reciprocal inhibition controls the oscillatory state in thalamic networks Neurocomputing<\/i>. 44-46:653-659.  <\/a><\/p>\n

<\/div>\n

78. Bacci A, Huguenard JR<\/B>, Prince DA (2002) Differential modulation of synaptic transmission by neuropeptide Y in rat neocortical neurons. Proc Natl Acad Sci U S A<\/i>. 99:17125-30. <\/a>PMC139280<\/a> <\/a><\/p>\n

<\/div>\n

77. Sun QQ, Huguenard JR<\/B>, Prince DA (2002) Somatostatin inhibits thalamic network oscillations in vitro: actions on the GABAergic neurons of the reticular nucleus. J Neurosci<\/i>. 22:5374-86. <\/a> <\/a><\/p>\n

<\/div>\n

76. Huguenard JR<\/B> (2002) Block of T -Type Ca(2+) Channels Is an Important Action of Succinimide Antiabsence Drugs. Epilepsy Curr<\/i>. 2:49-52. <\/a>PMC320968<\/a> <\/a><\/p>\n

<\/div>\n

75. Lin SH, Arai AC, Espa\u00c3\u00b1a RA, Berridge CW, Leslie FM, Huguenard JR<\/B>, Vergnes M, Civelli O (2002) Prolactin-releasing peptide (PrRP) promotes awakening and suppresses absence seizures. Neuroscience<\/i>. 114:229-38. <\/a> <\/a><\/p>\n

<\/div>\n

74. Kumar SS, Bacci A, Kharazia V, Huguenard JR<\/B> (2002) A developmental switch of AMPA receptor subunits in neocortical pyramidal neurons. J Neurosci<\/i>. 22:3005-15. <\/a> <\/a><\/p>\n

<\/div>\n

73. Xiang Z, Huguenard JR<\/B>, Prince DA (2002) Synaptic inhibition of pyramidal cells evoked by different interneuronal subtypes in layer v of rat visual cortex. J Neurophysiol<\/i>. 88:740-50. <\/a> F1000<\/a> <\/a><\/p>\n

<\/div>\n

72. Porcello DM, Ho CS, Joho RH, Huguenard JR<\/B> (2002) Resilient RTN fast spiking in Kv3.1 null mice suggests redundancy in the action potential repolarization mechanism. J Neurophysiol<\/i>. 87:1303-10. <\/a> <\/a><\/p>\n

<\/div>\n

71. Huguenard JR<\/B> (2002) Sodium channels: grit, determination, and persistence. Neuron<\/i>. 33:492-4. <\/a> <\/a><\/p>\n

<\/div>\n

70. Huguenard J<\/B> (2001) Thalamocortical Circuits and Excitability. Epilepsy Curr<\/i>. 1:13. <\/a>PMC320682<\/a> <\/a><\/p>\n

<\/div>\n

69. Sohal VS, Huguenard JR<\/B> (2001) Clonazepam suppresses oscillations in rat thalamic slices Neurocomputing<\/i>. 38-40:907-913.  <\/a><\/p>\n

<\/div>\n

68. Kumar SS, Huguenard JR<\/B> (2001) Properties of excitatory synaptic connections mediated by the corpus callosum in the developing rat neocortex. J Neurophysiol<\/i>. 86:2973-85. <\/a> <\/a><\/p>\n

<\/div>\n

67. Browne SH, Kang J, Akk G, Chiang LW, Schulman H, Huguenard JR<\/B>, Prince DA (2001) Kinetic and pharmacological properties of GABA(A) receptors in single thalamic neurons and GABA(A) subunit expression. J Neurophysiol<\/i>. 86:2312-22. <\/a> <\/a><\/p>\n

<\/div>\n

66. Jacobsen RB, Ulrich D, Huguenard JR<\/B> (2001) GABA(B) and NMDA receptors contribute to spindle-like oscillations in rat thalamus in vitro. J Neurophysiol<\/i>. 86:1365-75. <\/a> <\/a><\/p>\n

<\/div>\n

65. Sohal VS, Huguenard JR<\/B> (2001) It takes T to tango. Neuron<\/i>. 31:3-4. <\/a> <\/a><\/p>\n

<\/div>\n

64. Sun QQ, Akk G, Huguenard JR<\/B>, Prince DA (2001) Differential regulation of GABA release and neuronal excitability mediated by neuropeptide Y1 and Y2 receptors in rat thalamic neurons. J Physiol<\/i>. 531:81-94. <\/a>PMC2278458<\/a> <\/a><\/p>\n

<\/div>\n

63. Sun QQ, Huguenard JR<\/B>, Prince DA (2001) Neuropeptide Y receptors differentially modulate G-protein-activated inwardly rectifying K+ channels and high-voltage-activated Ca2+ channels in rat thalamic neurons. J Physiol<\/i>. 531:67-79. <\/a>PMC2278450<\/a> <\/a><\/p>\n

<\/div>\n

62. Destexhe A, Huguenard JR<\/B> (2000) Nonlinear thermodynamic models of voltage-dependent currents. J Comput Neurosci<\/i>. 9:259-70. <\/a> <\/a><\/p>\n

<\/div>\n

61. Huguenard JR<\/B> (2000) Circuit mechanisms of spike-wave discharge: are there similar underpinnings for centrotemporal spikes? Epilepsia<\/i>. 41:1076-7. <\/a> <\/a><\/p>\n

<\/div>\n

60. Huguenard JR<\/B> (2000) Reliability of axonal propagation: the spike doesn’t stop here. Proc Natl Acad Sci U S A<\/i>. 97:9349-50. <\/a>PMC34025<\/a> <\/a><\/p>\n

<\/div>\n

59. Sohal VS, Huntsman, MM, Huguenard JR<\/B> (2000) Reciprocal inhibitory connections produce desynchronizing phase lags during intrathalamic oscillations Neurocomputing<\/i>. 32: 509-516.  <\/a><\/p>\n

<\/div>\n

58. Sohal VS, Huntsman MM, Huguenard JR<\/B> (2000) Reciprocal inhibitory connections regulate the spatiotemporal properties of intrathalamic oscillations. J Neurosci<\/i>. 20:1735-45. <\/a> <\/a><\/p>\n

<\/div>\n

57. Huntsman MM, Huguenard JR<\/B> (2000) Nucleus-specific differences in GABA(A)-receptor-mediated inhibition are enhanced during thalamic development. J Neurophysiol<\/i>. 83:350-8. <\/a> <\/a><\/p>\n

<\/div>\n

56. Kang J, Huguenard JR<\/B>, Prince DA (2000) Voltage-gated potassium channels activated during action potentials in layer V neocortical pyramidal neurons. J Neurophysiol<\/i>. 83:70-80. <\/a> <\/a><\/p>\n

<\/div>\n

55. Sohal VS, Huguenard JR<\/B> (1999) Long-range connections synchronize rather than spread intrathalamic oscillatory activity: Computational modeling and in vitro electrophysiology Neurocomputing<\/i>. 26-27:525-531.  <\/a><\/p>\n

<\/div>\n

54. Huguenard JR<\/B> (1999) Neuronal circuitry of thalamocortical epilepsy and mechanisms of antiabsence drug action. Adv Neurol<\/i>. 79:991-9. <\/a> <\/a><\/p>\n

<\/div>\n

53. Huntsman MM, Porcello DM, Homanics GE, DeLorey TM, Huguenard JR<\/B> (1999) Reciprocal inhibitory connections and network synchrony in the mammalian thalamus. Science<\/i>. 283:541-3. <\/a> <\/a><\/p>\n

<\/div>\n

52. Huguenard JR<\/B> (1998) Low-voltage-activated (T-type) calcium-channel genes identified. Trends Neurosci<\/i>. 21:451-2. <\/a> <\/a><\/p>\n

<\/div>\n

51. Sohal VS, Huguenard JR<\/B> (1998) Long-range connections synchronize rather than spread intrathalamic oscillations: computational modeling and in vitro electrophysiology. J Neurophysiol<\/i>. 80:1736-51. <\/a> <\/a><\/p>\n

<\/div>\n

50. Xiang Z, Huguenard JR<\/B>, Prince DA (1998) Cholinergic switching within neocortical inhibitory networks. Science<\/i>. 281:985-8. <\/a> <\/a><\/p>\n

<\/div>\n

49. Huguenard JR<\/B> (1998) Anatomical and physiological considerations in thalamic rhythm generation. J Sleep Res<\/i>. 7 Suppl 1:24-9. <\/a> <\/a><\/p>\n

<\/div>\n

48. Destexhe A, Neubig M, Ulrich D, Huguenard J<\/B> (1998) Dendritic low-threshold calcium currents in thalamic relay cells. J Neurosci<\/i>. 18:3574-88. <\/a> <\/a><\/p>\n

<\/div>\n

47. Sohal VS, Cox CL, Huguenard JR<\/B> (1998) Localization of CCK receptors in thalamic reticular neurons: a modeling study. J Neurophysiol<\/i>. 79:2820-4. <\/a> <\/a><\/p>\n

<\/div>\n

46. Bennett BD, Huguenard JR<\/B>, Prince DA (1998) Adrenergic modulation of GABAA receptor-mediated inhibition in rat sensorimotor cortex. J Neurophysiol<\/i>. 79:937-46. <\/a> <\/a><\/p>\n

<\/div>\n

45. Xiang Z, Huguenard JR<\/B>, Prince DA (1998) GABAA receptor-mediated currents in interneurons and pyramidal cells of rat visual cortex. J Physiol<\/i>. 506 ( Pt 3):715-30. <\/a>PMC2230760<\/a> <\/a><\/p>\n

<\/div>\n

44. Zhang SJ, Huguenard JR<\/B>, Prince DA (1997) GABAA receptor-mediated Cl- currents in rat thalamic reticular and relay neurons. J Neurophysiol<\/i>. 78:2280-6. <\/a> <\/a><\/p>\n

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43. Ulrich D, Huguenard JR<\/B> (1997) GABA(A)-receptor-mediated rebound burst firing and burst shunting in thalamus. J Neurophysiol<\/i>. 78:1748-51. <\/a> <\/a><\/p>\n

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42. Cox CL, Huguenard JR<\/B>, Prince DA (1997) Nucleus reticularis neurons mediate diverse inhibitory effects in thalamus. Proc Natl Acad Sci U S A<\/i>. 94:8854-9. <\/a>PMC23165<\/a> <\/a><\/p>\n

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41. Bennett BD, Huguenard JR<\/B>, Prince DA (1997) Adrenoceptor-mediated elevation of ambient GABA levels activates presynaptic GABA(B) receptors in rat sensorimotor cortex. J Neurophysiol<\/i>. 78:561-6. <\/a> <\/a><\/p>\n

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40. Ulrich D, Huguenard JR<\/B> (1997) Nucleus-specific chloride homeostasis in rat thalamus. J Neurosci<\/i>. 17:2348-54. <\/a> <\/a><\/p>\n

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39. Cox CL, Huguenard JR<\/B>, Prince DA (1997) Peptidergic modulation of intrathalamic circuit activity in vitro: actions of cholecystokinin. J Neurosci<\/i>. 17:70-82. <\/a> <\/a><\/p>\n

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38. Kang J, Huguenard JR<\/B>, Prince DA (1996) Two types of BK channels in immature rat neocortical pyramidal neurons. J Neurophysiol<\/i>. 76:4194-7. <\/a> <\/a><\/p>\n

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37. Ulrich D, Huguenard JR<\/B> (1996) Gamma-aminobutyric acid type B receptor-dependent burst-firing in thalamic neurons: a dynamic clamp study. Proc Natl Acad Sci U S A<\/i>. 93:13245-9. <\/a>PMC24078<\/a> <\/a><\/p>\n

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36. Kang J, Huguenard JR<\/B>, Prince DA (1996) Development of BK channels in neocortical pyramidal neurons. J Neurophysiol<\/i>. 76:188-98. <\/a> <\/a><\/p>\n

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35. Ulrich D, Huguenard JR<\/B> (1996) GABAB receptor-mediated responses in GABAergic projection neurones of rat nucleus reticularis thalami in vitro. J Physiol<\/i>. 493 ( Pt 3):845-54. <\/a>PMC1159030<\/a> <\/a><\/p>\n

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34. Cox CL, Huguenard JR<\/B>, Prince DA (1996) Heterogeneous axonal arborizations of rat thalamic reticular neurons in the ventrobasal nucleus. J Comp Neurol<\/i>. 366:416-30. <\/a> <\/a><\/p>\n

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33. Huguenard JR<\/B>, Chung JM, Prince DA (1996) Excitability changes in thalamic and neocortical neurons after injury. Epilepsy Res Suppl<\/i>. 12:129-35. <\/a> <\/a><\/p>\n

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32. Huguenard JR<\/B> (1996) Low-threshold calcium currents in central nervous system neurons. Annu Rev Physiol<\/i>. 58:329-48. <\/a> <\/a><\/p>\n

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31. Destexhe A, Contreras D, Steriade M, Sejnowski TJ, Huguenard JR<\/B> (1996) In vivo, in vitro, and computational analysis of dendritic calcium currents in thalamic reticular neurons. J Neurosci<\/i>. 16:169-85. <\/a> <\/a><\/p>\n

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30. Mainen ZF, Joerges J, Huguenard JR<\/B>, Sejnowski TJ (1995) A model of spike initiation in neocortical pyramidal neurons. Neuron<\/i>. 15:1427-39. <\/a> <\/a><\/p>\n

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29. Ulrich D, Huguenard JR<\/B> (1995) Purinergic inhibition of GABA and glutamate release in the thalamus: implications for thalamic network activity. Neuron<\/i>. 15:909-18. <\/a> <\/a><\/p>\n

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28. Cox CL, Huguenard JR<\/B>, Prince DA (1995) Cholecystokinin depolarizes rat thalamic reticular neurons by suppressing a K+ conductance. J Neurophysiol<\/i>. 74:990-1000. <\/a> <\/a><\/p>\n

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27. Huguenard JR<\/B>, Prince DA (1994) Intrathalamic rhythmicity studied in vitro: nominal T-current modulation causes robust antioscillatory effects. J Neurosci<\/i>. 14:5485-502. <\/a> <\/a><\/p>\n

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26. Huguenard JR<\/B>, Prince DA (1994) Clonazepam suppresses GABAB-mediated inhibition in thalamic relay neurons through effects in nucleus reticularis. J Neurophysiol<\/i>. 71:2576-81. <\/a> <\/a><\/p>\n

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25. McCormick DA, Wang Z, Huguenard J<\/B> (1993) Neurotransmitter control of neocortical neuronal activity and excitability. Cereb Cortex<\/i>. 3:387-98. <\/a> <\/a><\/p>\n

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24. Chung JM, Huguenard JR<\/B>, Prince DA (1993) Transient enhancement of low-threshold calcium current in thalamic relay neurons after corticectomy. J Neurophysiol<\/i>. 70:20-7. <\/a> <\/a><\/p>\n

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23. Huguenard JR<\/B>, Gutnick MJ, Prince DA (1993) Transient Ca2+ currents in neurons isolated from rat lateral habenula. J Neurophysiol<\/i>. 70:158-66. <\/a> <\/a><\/p>\n

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22. Huguenard JR<\/B>, Prince DA (1992) A novel T-type current underlies prolonged Ca(2+)-dependent burst firing in GABAergic neurons of rat thalamic reticular nucleus. J Neurosci<\/i>. 12:3804-17. <\/a> <\/a><\/p>\n

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21. McCormick DA, Huguenard JR<\/B> (1992) A model of the electrophysiological properties of thalamocortical relay neurons. J Neurophysiol<\/i>. 68:1384-400. <\/a> <\/a><\/p>\n

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20. Huguenard JR<\/B>, McCormick DA (1992) Simulation of the currents involved in rhythmic oscillations in thalamic relay neurons. J Neurophysiol<\/i>. 68:1373-83. <\/a> <\/a><\/p>\n

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19. Coulter DA, Huguenard JR<\/B>, Prince DA (1991) Mechanism of block of thalamic T-type Ca2+ channels by petit mal anticonvulsants Exp. Brain Res.: Physiology, Pharmacology and Development of Epileptogenic Phenomena, M.R. Klee (ed.) Frankfurt, Series<\/i>. 20: 201-204.  <\/a><\/p>\n

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18. Huguenard JR<\/B>, Coulter DA, Prince DA (1991) Properties of the low-threshold calcium current in thalamic relay neurons: Recovery from inactivation in relation to the control of repetitive burst generation Exp. Brain Res.: Physiology, Pharmacology and Development of Epileptogenic Phenomena, M.R. Klee (ed.) Frankfurt, Series<\/i>. 20: 39-43.  <\/a><\/p>\n

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17. Huguenard JR<\/B>, Prince DA (1991) Slow inactivation of a TEA-sensitive K current in acutely isolated rat thalamic relay neurons. J Neurophysiol<\/i>. 66:1316-28. <\/a> <\/a><\/p>\n

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16. Huguenard JR<\/B>, Coulter DA, Prince DA (1991) A fast transient potassium current in thalamic relay neurons: kinetics of activation and inactivation. J Neurophysiol<\/i>. 66:1304-15. <\/a> <\/a><\/p>\n

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15. Hamill OP, Huguenard JR<\/B>, Prince DA (1991) Patch-clamp studies of voltage-gated currents in identified neurons of the rat cerebral cortex. Cereb Cortex<\/i>. 1:48-61. <\/a> <\/a><\/p>\n

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14. Coulter DA, Huguenard JR<\/B>, Prince DA (1990) Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction. Br J Pharmacol<\/i>. 100:800-6. <\/a>PMC1917607<\/a> <\/a><\/p>\n

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13. Coulter DA, Huguenard JR<\/B>, Prince DA (1990) Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: GABA current blockade. Br J Pharmacol<\/i>. 100:807-13. <\/a>PMC1917578<\/a> <\/a><\/p>\n

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12. Coulter DA, Huguenard JR<\/B>, Prince DA (1989) Calcium currents in rat thalamocortical relay neurones: kinetic properties of the transient, low-threshold current. J Physiol<\/i>. 414:587-604. <\/a>PMC1189159<\/a> <\/a><\/p>\n

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11. Coulter DA, Huguenard JR<\/B>, Prince DA (1989) Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons. Ann Neurol<\/i>. 25:582-93. <\/a> <\/a><\/p>\n

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10. Huguenard JR<\/B>, Hamill OP, Prince DA (1989) Sodium channels in dendrites of rat cortical pyramidal neurons. Proc Natl Acad Sci U S A<\/i>. 86:2473-7. <\/a>PMC286935<\/a> <\/a><\/p>\n

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9. Coulter DA, Huguenard JR<\/B>, Prince DA (1989) Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons. Neurosci Lett<\/i>. 98:74-8. <\/a> <\/a><\/p>\n

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8. Shen JM, Huguenard JR<\/B>, Kriegstein AR (1988) Development of GABA responsiveness in embryonic turtle cortical neurons. Neurosci Lett<\/i>. 89:335-41. <\/a> <\/a><\/p>\n

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7. Huguenard JR<\/B>, Hamill OP, Prince DA (1988) Developmental changes in Na+ conductances in rat neocortical neurons: appearance of a slowly inactivating component. J Neurophysiol<\/i>. 59:778-95. <\/a> <\/a><\/p>\n

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6. Huguenard JR<\/B>, Alger BE (1986) Whole-cell voltage-clamp study of the fading of GABA-activated currents in acutely dissociated hippocampal neurons. J Neurophysiol<\/i>. 56:1-18. <\/a> <\/a><\/p>\n

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5. Lewis DV, Huguenard JR<\/B>, Anderson WW, Wilson WA (1986) Membrane currents underlying bursting pacemaker activity and spike frequency adaptation in invertebrates. Adv Neurol<\/i>. 44:235-61. <\/a> <\/a><\/p>\n

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4. Huguenard JR<\/B>, Wilson WA (1985) Barbiturate-induced alterations in the kinetic parameters of slow outward current in Aplysia giant neurons. J Pharmacol Exp Ther<\/i>. 234:821-9. <\/a> <\/a><\/p>\n

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3. Huguenard JR<\/B>, Zbicz KL, Lewis DV, Evans GJ, Wilson WA (1985) The ionic mechanism of the slow outward current in Aplysia neurons. J Neurophysiol<\/i>. 54:449-61. <\/a> <\/a><\/p>\n

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2. Huguenard JR<\/B>, Wilson WA (1985) Suppression of repetitive firing of neurons by diphenylbarbituric acid. J Pharmacol Exp Ther<\/i>. 232:228-31. <\/a> <\/a><\/p>\n

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1. Bartolome J, Huguenard J<\/B>, Slotkin TA (1980) Role of ornithine decarboxylase in cardiac growth and hypertrophy. Science<\/i>. 210:793-4. <\/a> <\/a><\/p>\n<\/p>\n

<\/p>\n
Preprints<\/div>\n

  Go to Peer Reviewed<\/a><\/p>\n

<\/H3><\/center><\/p>\n

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10. Devienne G, Vantomme G, and Huguenard JR<\/B> (2025) Disrupted Development of the mPFC-Thalamic Circuit in the Mouse Shank-\/- model of Autism Molecular Psychiatry<\/i>. doi: https:\/\/doi.org\/10.1101\/2024.09.09.612160.  <\/a><\/p>\n

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9. Jang SS, Takahashi F, Huguenard JR<\/B> (2025) Reticular Thalamic Hyperexcitability Drives Autism Spectrum Disorder Behaviors in the Cntnap2 Model of Autism. bioRxiv<\/i>. https:\/\/www.biorxiv.org\/content\/10.1101\/2025.03.21.644680v1. <\/a> <\/a><\/p>\n

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8. Jang SS, Agranonik N, Huguenard JR<\/B> (2025) Actions of the Anti-Seizure Drug Carbamazepine in the Thalamic Reticular Nucleus: Potential Mechanism of Aggravating Absence Seizures. bioRxiv<\/i>. https:\/\/doi.org\/10.1101\/2025.02.03.636080. <\/a>11838511<\/a> <\/a><\/p>\n

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7. Gomez-Frittelli J, Devienne G, Travis L, Kyloh MA, Duan X, Hibberd TJ, Spencer NJ, Huguenard JR<\/B>, Kaltschmidt JA (2024) Synaptic cell adhesion molecule Cdh6 identifies a class of sensory neurons with novel functions in colonic motility. bioRxiv<\/i>. DOI: 10.1101\/2024.08.06.606748. <\/a>11326146<\/a> <\/a><\/p>\n

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6. Vantomme G, Devienne G, Hull JM, Huguenard JR<\/B> (2024) Reuniens thalamus recruits recurrent excitation in medial prefrontal cortex. bioRxiv<\/i>. DOI: 10.1101\/2024.05.31.596906. <\/a> <\/a><\/p>\n

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5. Christine Joy Liu, Jordan Sorokin, Surya Ganguli, John Huguenard<\/B> (2020) An Evolving-Dynamic Network Activity Approach to Epileptic Seizure Prediction using Machine Learning BioRxiv<\/i>. https:\/\/www.biorxiv.org\/content\/10.1101\/2020.11.29.402461v1. <\/a> <\/a><\/p>\n

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4. Anna V. Elleman, Gabrielle Devienne, Christopher D. Makinson, Allison L. Haynes, John R. Huguenard<\/B>,
\n Justin Du Bois (2020) Precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin BioRxiv<\/i>. https:\/\/www.biorxiv.org\/content\/10.1101\/2020.11.18.389130v1. <\/a> Final published version, paper<\/i> #193<\/a>  <\/a><\/p>\n

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3. Juliet K Knowles, Caroline Soane, Eleanor Frost, Lydia T Tam, Danielle Fraga, Haojun Xu, Ankita Batra, Lijun Ni, Katlin Villar, Tristan Saucedo, John Huguenard<\/B>, Michelle Monje (2020) Maladaptive myelination promotes epileptogenesis in absence epilepsy BioRxiv<\/i>. https:\/\/www.biorxiv.org\/content\/10.1101\/2020.08.20.260083v1. <\/a> Final published version, paper<\/i> #195<\/a>  F1000<\/a> <\/a><\/p>\n

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2. Adam C Lu, Christine Kyuyoung Lee, Max Kleiman-Weiner, Brian Truong, Megan Wang, John R Huguenard<\/B>, Mark P Beenhakkerre (2020) Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic network oscillations BioRxiv<\/i>. https:\/\/www.biorxiv.org\/content\/10.1101\/2020.06.02.129601v1. <\/a> Final published version, paper<\/i> #187<\/a>  <\/a><\/p>\n

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1. Jordan M Sorokin, Alex H Williams, Surya Ganguli, John R Huguenard<\/B> (2020) Thalamic activity patterns unfolding over multiple time scales predict seizure onset in absence epilepsy BioRxiv<\/i>. https:\/\/www.biorxiv.org\/content\/10.1101\/2020.03.04.976688v1. <\/a> <\/a><\/p><\/p>\n<\/div>

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