Module VI. Gene therapy for necrotic neurological disease
Robert Sapolsky
Neurology 205, Clinical Neuroscience,Winter Quarter, 1999- 2000
There is now sufficient knowledge about the events mediating neuron death
following hypoxia-ischemia or seizure so as to attempt to intervene with
protective gene transfer techniques. In this lecture, Robert Sapolsky will
review the emerging literature concerning the use of viral vectors for
deliverying neuroprotective genes in order to decrease damage associated
with such necrotic insults. He will concentrate on a) issues in the choice
and construction of viral vectors; b) transgenes that have been shown to
be neuroprotective; c) whether sparing of neuronal survival with a gene
therapy intervention necessarily translates into sparing of neuronal function;
d) the design of insult-inducible vector systems; e) pilot data regarding
the efficacy of these approaches in human brain tissue.
This week's papers, to be presented on Tuesday, February 15 at 7PM,
by Joyce Liao and Anand Desai, will review current progress in gene therapy
in neurodegenerative diseases.
Gene
therapy using viral vectors for acute neurologic insults
PDF version of above
IMPACT RATING (1 is low, 10 is high)
Module VI. Gene therapy in necrotic neurological
disease
[Optimism regarding viral vector gene therapy
in stroke]
Summary: mean & SD = 3.9 +/- 1.7, Mode
= 5, Median = 4, N = 11, range = 1-6
Attenuation of Ischemia-Induced Cellular and Behavioral
Deficits by X Chromosome-Linked Inhibitor of Apoptosis Protein Overexpression
in the Rat Hippocampus
IMPACT RATING (1 is low, 10 is high)
Module VI. Gene therapy in necrotic neurological
disease [XIAP overexpression as tx]
Summary: mean & SD = 3.8 +/- 1.7, Mode
= 2, Median = 4, N = 11, range = 2-7