Module V. How to stop a seizure (...without inducing sleep)

John Huguenard

Neurology 205, Clinical Neuroscience,Winter Quarter, 1999- 2000

This week's papers, to be presented on Tuesday, February 8 at 7PM, by David Nadell and Jim Weimann address the issues of functional specificity of neurotransmitter receptors and molecular changes in receptor subtypes after seizures.

GABA synapses enter the molecular big time

Selective changes in single cell GABAA receptor subunit expression and function in temporal lobe epilepsy

IMPACT RATING (1 is low, 10 is high)
Module V. Seizure pharmacotherapy [Are reactive changes in GABA receptors epileptogenic?]
Summary: mean & SD = 6.1 +/- 0.7, Mode = 6, Median = 6, N = 10, range = 5-7

Benzodiazepine actions mediated by specific gamma-aminobutyric acid (A) receptor subtypes

IMPACT RATING (1 is low, 10 is high)
Module V. Seizure pharmacotherapy [Targeted GABA-a subunit pharmacology]
Summary: mean & SD = 8.0 +/- 0.7, Mode = 8, Median = 8, N = 10, range = 7-9