Module IX. Alzheimer's Disease

Bill Mobley

Neurology 205, Clinical Neuroscience,Winter Quarter, 1999- 2000


The papers for presentation by Rachel Henderson and Greg Jefferis will be:

De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 1999 398:518-22.

Commentary: Hardy J, Israel A. Alzheimer's disease. In search of gamma-secretase. Nature. 1999 398:466-7.

IMPACT RATING (1 is low, 10 is high)
Module IX. Alzheimer's [PSI/gSec/Notch]
Summary: mean & SD = 5.5 +/- 1.2, Mode =  4, Median =  6, N  =  8, range = 4-7

Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Liao Z, Lieberburg I, Motter R, Mutter L, Soriano F, Shopp G, Vasquez N, Vandevert C, Walker S, Wogulis M, Yednock T, Games D, Seubert P.  Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature. 1999 400:173-7.

Commentary: St George-Hyslop PH, Westaway DA. Alzheimer's disease. Antibody clears senile plaques. Nature. 1999 400:116-7.

IMPACT RATING (1 is low, 10 is high)
Module IX. Alzheimer's [Immunization]
Summary: mean & SD = 6.3 +/- 1.0, Mode =  6, Median =  6, N  =  8, range = 5-8