A Therapeutic Vaccine Approach to Stimulate Axon Regeneration in the Adult Mammalian Spinal Cord
IMPACT RATING (1 is low, 10 is high)
Module IV. CNS neuronal regeneration [Subacute
MS as a tx]
Summary: mean & SD = 8.4 +/- 0.9, Mode
= 8, Median = 8, N = 11, range = 7-10
Regeneration of adult axons in white matter tracts of the central nervous system
Optic Nerve Crush: Axonal Responses in Wild-Type and bcl-2 Transgenic Mice
IMPACT RATING (1 is low, 10 is high)
Module IV. CNS neuronal regeneration [BCL2
overexpression as tx]
Summary: mean & SD = 4.4 +/- 1.4, Mode
= 4, Median = 4, N = 11, range = 1-7
Supplemental information for this module:
1) The patient presentation will be Mr. Henry Lewenstein. The full
story of his life as a quadraplegic can be found at
this
site
2) In the Jan 24 issue of Nature will be 3 papers on the cloning of
Nogo, a myelin inhibitor thought to be responsible for preventing axonal
regeneration. The three groups are Schwab, Strittmatter, and Walsh. In
addition, in that issue will be a News and Views article by Jeff Goldberg
and Ben Barres summarizing the Nogo story. Finally, the "feature of the
week" on the Nature web site next week
will concern regeneration. This site will contain pointers to many other
sites of interest concerning spinal cord injury.