Module III. Stroke, neurodegeneration

Midori Yenari, David Tong

Neurology 205, Clinical Neuroscience,Winter Quarter, 1999- 2000

David Tong will describe clinical presentations of the major stroke syndromes, then classify stroke mechanisms by subtype (lacunar, large vessel, embolic, hemorrhagic, etc.). Mimi Yenari will discuss the ischemic cascade as it pertains to calcium toxicity, excitotoxicity, nitric oxide and other free radical generation and leukocyte recruitment.

This module's papers, to be presented on Tuesday, February 8 at 7PM, by Shelley Emond and David Nadell address potential mechanisms of neurotoxicity in stroke.

Neuronal Protection in Stroke by an sLex-Glycosylated Complement Inhibitory Protein

IMPACT RATING (1 is low, 10 is high)
Module III. Stroke [sCR1sLex]
Summary: mean & SD = 5.2 +/- 1.0, Mode = 5, Median = 5, N = 11, range = 4-7

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

IMPACT RATING (1 is low, 10 is high)
Module III. Stroke [PARP]
Summary: mean & SD = 5.5 +/- 1.8, Mode = 6, Median = 6, N = 11, range = 2-7